Perioperative Blood Transfusion in Open Liver Resection

Blood Loss, Postoperative Clinical Trial

Official title:

The Risk Factors for Perioperative Blood Transfusion in Open Liver Resection, a Retrospective Cohort Study Development of a Transfusion Scoring System to Predict the Requirement for Perioperative Blood Transfusion in Open Liver Resection

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06189911
• Other study ID #: ANE-2564-08020
• Status: Completed
• Start date: January 1, 2006
• Est. completion date: January 1, 2023

Study information

• Verified date: February 2024
• Source: Chiang Mai University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This observational study is specifically designed to identify the pre-operative risk factors that significantly contribute to perioperative packed red cell transfusions in open liver resection procedures.

The main question it aims to answer are:

1. What are the risk factors of peri-operative blood transfusion in open liver resection procedures

2. What are the difference outcomes between patients who receive blood transfusion and the other group.

Researcher will compare perioperative factor and post operative outcomes between transfused and non-transfused group

Description:

After approval of the study protocol from the institutional review board of Chiangmai University (Approval number: ANE-2564-08020), we performed a retrospective review of all patients who underwent an elective open liver resection in our specialized hepato-biliary center from January 2006 through December 2017. This retrospective inquiry comprised 808 patients.

The data was systematically retrieved from electronic medical records. Baseline characteristics including age, gender, body mass index (BMI), co-morbidity, American Society of Anesthesiologists (ASA) classification, diagnosis, hepatitis profile, Child-Pugh classification, cirrhosis, the largest tumor size, previous liver resection, and pre-operative laboratory investigations were collected.

The following intra-operative data were collected: type of liver resection, hilar resection, vascular reconstruction, volume and type of fluid administration, estimated blood loss, packed red cell and blood product transfusion, and operation time. The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1201
• Est. completion date: January 1, 2023
• Est. primary completion date: December 31, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• All genders age above 18 year old who underwent open liver resection from 2006-2017

• Elective open liver resection

Exclusion Criteria:

• Patients who death during the course of a surgical operation

Related Conditions & MeSH terms

• Blood Loss, Postoperative
• Postoperative Hemorrhage

Intervention

Procedure:
• Open liver resection
The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Chiang Mai University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the pre-operative risk factors of perioperative packed red cell transfusions in open liver resection procedures.	Significant risk factors for perioperative blood transfusion were determined by factors with a p-value < 0.05 derived from the multivariable logistic regression analysis. This analysis facilitated adjustments for potential confounders to identify the independent risk factors associated with perioperative blood transfusion	the transfusion of packed red cells during the operation and 48 hours after surgery