The Effect of Artificial Sweeteners on Blood Glucose Response

Blood Glucose Clinical Trial

Official title:

The Effect of Artificial Sweeteners on Blood Glucose Response

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT01246492
• Other study ID #: 34AK1
• Status: Withdrawn
• Phase: N/A
• First received: November 22, 2010
• Last updated: May 17, 2012
• Start date: November 2010
• Est. completion date: May 2011

Study information

• Verified date: May 2012
• Source: Northumbria University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United Kingdom: Research Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether the presece of the artificial sweeteners aspartame, saccharin and asceulfame-k affect the blood glucose responses to an orally incested glucose solution.

Description:

Sweet taste receptors, similar to those located on the lingual taste buds have been located along in the lining of the gut. Recent studies have demonstrated that activation of these sweetness taste receptors, either by sugars such as glucose, fructose, lactose, or artificial sweeteners such as saccharin and aspartame can influence the way nutrients, including glucose are absorbed from the gut into the bloodstream. Studies in animal models have shown that activation of the sweet taste receptors can increase the expression of the sodium-dependant glucose transporter 1 (SGLT1) and glucose transporter 2 (GLUT2) which transport glucose from the lumen into the bloodstream. Thus providing a potential mechanism by which glucose uptake can be regulated. Although artificial sweeteners stimulate the sweet taste receptors, they have little nutritive value, so that when they are consumed in the absence of any other nutrients there is little effect on blood glucose response. However, the effects of consuming artificial sweeteners in combination with sugars such as glucose is unclear. The purpose of this study is to investigate whether the addition of artificial sweeteners to an orally consumed glucose solution affects the rate at which the glucose appears in the blood.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: May 2011
• Est. primary completion date: May 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Healthy subjects

• Aged 18-45 years

• BMI (19-25 kg/m2)

• Weight stable in past 3 months

Exclusion Criteria:

• Smoking

• Females who are pregnant of breastfeeding

• Regular intake of emdication, other than females taking oral contraceptives

• Medical illness

• Gastrointestinal disorders

• Food allergies

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Appetite
• Blood Glucose
• Intestinal Absorption
• Nutrient Sensing
• Taste Receptors

Intervention

Dietary Supplement:
• Artificial Sweeteners
A 400mL drink sweetened with 45g glucose and artificial sweetener will be consumed orally

Locations

Country	Name	City	State
United Kingdom	Brain, Performance and Nutrition Research Centre- Northumbria University	Newcastle-Upon Tyne

Sponsors (1)

Lead Sponsor	Collaborator
Northumbria University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood glucose response	Blood glucose will be determined at baseline and for 90 min following the consumption of the test drinks	90 min	No
Secondary	Subjective appetite	Subjective appetite ratings will be collected at baseline and for 90 min following the consumption of the test drinks	90 min	No