Eccentric Resistance Training With Blood Flow Restriction on Muscle Function

Blood Flow Restriction Clinical Trial

Official title:

Effects of Blood Flow Restriction During Multiple-joint Eccentric Resistance Training on Muscle Morphology and Function of the Lower Body.

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT04977804
• Other study ID #: 12042b
• Status: Withdrawn
• Phase: N/A
• Start date: March 30, 2024
• Est. completion date: December 1, 2025

Study information

• Verified date: November 2023
• Source: Utah State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study will determine the effects of adding blood flow restriction to eccentric training to assess whether this increases the improvements of muscle strength and size.

Description:

Subjects will be randomly assigned to two groups: an eccentric only resistance training group or an eccentric training plus blood flow restriction group. Subjects will train at a moderately low intensity on a multiple-joint eccentric device. Those in the blood flow restriction will wear blood flow restriction cuffs on their upper thighs to reduce blood flow during the brief protocol. The training session will occur twice per week and will last ~5 minutes, including a one minute warm up, a one minute cool down and a three minute workout phase. The training program will last 7 weeks. Testing will be conducted at baseline (following a one session familiarization), 4 weeks and after the end of the 7 week training period. Assessments will focus on muscle strength, function, and morphology (size).

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: December 1, 2025
• Est. primary completion date: June 1, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• 18-30 years of age

• currently engaged in some form of resistance training between 1-3 times per week

• must have been training aerobically, but no more than 3 hours a week for the past six months

Exclusion Criteria:

• Must not have had any surgery of the lower limbs within the past 1 year period

• Must not have any neuromuscular disorder (e.g., Muscular dystrophy etc.)

• < 76 inches tall (in order to fit on the training machine)

• Maximal strength of < 725 lbs for the eccentric training device

• If any of the subjects are pregnant or plan to be pregnant in the duration of the protocol.

For those randomized to the BFR group, if any of the subject's thighs are too large for the BFR cuffs (greater than 68 cm).

Related Conditions & MeSH terms

• Blood Flow Restriction

Intervention

Other:
• Exercise
The interventions are a form or exercise, specifically resistance exercise.
• Eccentric plus blood-flow restriction
Eccentric plus blood-flow restriction

Locations

Country	Name	City	State
United States	Utah State Universtiy	Logan	Utah

Sponsors (1)

Lead Sponsor	Collaborator
Utah State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Eccentron maximal muscle strength	Eccentric muscle strength will be assessed via Eccentron (BTE Technologies, Inc., USA), an seated isokinetic dynamometer.	7 weeks
Primary	Local muscle hypertrophy	Muscle size changes of the quadriceps muscle measured an ultrasound device (GE NextGen LOGIQ, Tampa, Florida, USA).	7 weeks
Primary	Muscle mass	dual energy x-ray absorptiometry device (DEXA) the Hologic Horizon W Dual X-ray absorptiometry (Hologic Canada ULC, Mississauga, ON, Canada) will be used to assess appendicular (lower body) mean mass.	7 weeks
Primary	Muscle function	Vertical jump height will assess 3 maximal countermovement attempts on a jump mat (Just Jump Technologies, Huntsville, AL, USA) that measures jump height based on flight time.	7 weeks
Secondary	Muscle soreness	local muscle soreness will be assessed throughout the duration of the intervention period using a Wagner force algometer.	7 weeks