Effect of Different Liquids Intake in Vasovagal Reaction After Whole Blood Donation

Blood Donation Clinical Trial

Official title:

Effect of Different Liquids Intake in Vasovagal Reaction After Whole Blood Donation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05319951
• Other study ID #: Different liquids intake
• Status: Completed
• Phase: N/A
• Start date: January 20, 2021
• Est. completion date: December 31, 2021

Study information

• Verified date: September 2022
• Source: Guangzhou Blood Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

we compared the effect of 3 different kinds of liquids (water, Oral Rehydration Salt 3 and white granulated sugar water) intake in Vasovagal Reaction After Whole Blood Donation

Description:

Vasovagal reaction is the most common type of blood donation reaction. The main cause of this reaction is the decrease of blood volume. Therefore, fluid supplement before blood donation has been proved to be effective in preventing the vagal reaction after blood donation. It was proved that isotonic (sugar & salt) drink intake before blood donation had a significant effect on reducing vasovagal reaction. However, in 2002, WHO recommended the new reduced osmolarity rehydration formula with better taste. Oral Rehydration Salt 3 has been produced according to WHO formula with standard ingredient and easy to prepare. In addition, in Guangdong culture, sugar water is regarded as a tonic, more easily accepted. So, the aim of our study was to compare the effects of 500 ml water with Oral Rehydration Salt 3, white granulated sugar and conventional recommended water intake prior to blood donation on blood donation reaction after whole blood donation, in order to understand the effect of different liquid supplement on blood donation reaction and the willingness of blood donation again.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 6250
• Est. completion date: December 31, 2021
• Est. primary completion date: November 26, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:All blood donors donated whole blood in Guangzhou Blood Center during study. - Exclusion Criteria:Blood donors who were deferral by blood screening result and other situations. -

Related Conditions & MeSH terms

• Blood Donation
• Syncope, Vasovagal

Intervention

Drug:
• Oral Rehydration Salts power (iii)
Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

Dietary Supplement:
• water with white granulated sugar
Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.
• water
Recommend the subjects to drink up 500ml water in 20 minutes prior to donation.

Locations

Country	Name	City	State
China	Guangzhou Blood Center	Guangzhou	Guangdong

Sponsors (1)

Lead Sponsor	Collaborator
Guangzhou Blood Center

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	vasovagal reaction rate	vasovagal reaction rate in three groups	1-3days
Secondary	rate of willingness to donate blood again	rate of willingness to donate blood again in three groups	3days