Blind Clinical Trial
— SCTVIOfficial title:
Spatial Cognitive Training in Visual Impairment
NCT number | NCT03423654 |
Other study ID # | C2243-P |
Secondary ID | |
Status | Terminated |
Phase | N/A |
First received | |
Last updated | |
Start date | March 30, 2018 |
Est. completion date | June 30, 2019 |
Verified date | June 2020 |
Source | VA Office of Research and Development |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study is designed to see if doing regular training on a spatial imagery task leads to improvements in the ability to do the trained spatial imagery task and in the ability to get around in everyday activities.
Status | Terminated |
Enrollment | 6 |
Est. completion date | June 30, 2019 |
Est. primary completion date | June 30, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 50 Years and older |
Eligibility |
Inclusion Criteria: - Inability to perceive visual stimuli, i.e. no light perception, with stable visual loss over the past year - The investigators anticipate that causes of blindness will be ocular, including: - glaucoma - diabetic retinopathy and macular degeneration - the most common causes of blindness in Veterans - as well as possibly late-onset Leber's optic atrophy and ocular trauma (in the absence of TBI) - To minimize heterogeneity due to variations in age and the duration of visual loss, the investigators will restrict enrollment to Veterans and Non-Veterans over the age of 50 who lost light perception within the last 5 years, and who have completed standard O&M training. - From a practical standpoint, this also enables the investigators to focus on participants who can potentially benefit most from the proposed intervention. Exclusion Criteria: - Participants will be excluded if they have any neurological condition, such as: - TBI - history of blast exposure - stroke - brain tumors - epilepsy, etc. - Participants will also be excluded if MRI scanning is contra-indicated, e.g.: - due to an implanted device such as a pacemaker - or foreign bodies of ferromagnetic nature - Cognitive screening will be performed using the Repeatable Battery for Assessment of Neuropsychological Status (RBANS, Randolph, 1998) and participants with cognitive impairment will be excluded based on a score of 1.5 SD below the mean for the Verbal Memory Index. - The investigators will test participants' hearing using a validated screening questionnaire (Screening Version of the Hearing Handicap Inventory for the Elderly, HHIE-S, Wentry & Weinstein, 1983, Lichtenstein et al., 1988) followed by assessment of audiometric pure tone (0.5, 1.0, 2.0, 4.0 KHz) hearing thresholds in the CVNR sound booth. - Participants with more than mild hearing loss (HHIE score >8 or audiometric thresholds >40dB) will be excluded (Wentry & Weinstein, 1983; Wilson, 2009), given that the investigators are relying on audio cues. - The investigators will also exclude visually impaired Veterans who are dependent on a wheelchair or scooter for mobility, as they will not be able to take part in the real-world task. |
Country | Name | City | State |
---|---|---|---|
United States | Emory University | Atlanta | Georgia |
United States | Atlanta VA Medical and Rehab Center, Decatur, GA | Decatur | Georgia |
Lead Sponsor | Collaborator |
---|---|
VA Office of Research and Development |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Spatial Ability | Ability to orient to where participants began at the beginning of task. Using a 5x5 grid on testing device, a 5x5 grid that the participant will have to walk, and a 5x5 grid during task in MRI. | 1 month |
Status | Clinical Trial | Phase | |
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