Blepharitis Clinical Trial
Official title:
Effect of Probiotics on the Occurrence of Blepharitis in Adults and Children
The alteration of the intestinal microbiota through the use of specific probiotics can improve the clinical course of blepharitis by restoring intestinal and immune homeostasis. The purpose of this study is to define the possible positive impact of probiotics on patients with blepharitis.
From recent studies, it has emerged that the gut microbiota is a possible responsible for the stimulation of the innate immune response and its role in the pathogenesis of autoimmune diseases has been deepened. Several clinical studies, in fact, support the existence of a connection between changes in the commensal intestinal microbiota ("dysbiosis") and autoimmune diseases. It has been seen that also ocular conditions like chalaziosis and uveitis are tied to dysbiosis. In addition, in a recent study probiotics were found to be safe and effective in the treatment of chalaziosis in children. Other eye conditions that may be affected by changes in the gut microbiome are dry eye syndrome and blepharitis. Under these conditions, a reduction in globet cells has often been noted. These cells produce the mucins present on the ocular surface, and therefore, their reduction involves the production of a thin and ineffective tear film. Therefore, the study will cover patients with blepharitis (both adults and children), treated with specific probiotics to be taken daily. Patients will then undergo a full ophthalmological examination each week for the first month, and then monthly until complete recovery for at least 6 months. In addition, at the time of enlistment and complete recovery, after venous sampling, the following biomarkers will be analyzed with cytometer and ELISA: TNFα and lymphocyte subpopulations. With this study, therefore, the aim is to define the possible positive impact of probiotics on patients with blepharitis. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04475432 -
Safety and Efficacy of TP-03 for the Treatment of Demodex Blepharitis
|
Phase 2/Phase 3 | |
| Completed |
NCT05062564 -
Efficacy of LipiFlow in Patients Affected by Meibomian Gland Dysfunction in Reducing Post-cataract Surgery Dry Eye
|
N/A | |
| Completed |
NCT05629390 -
Trial to Evaluate the Efficacy and Safety of TP-03, LIBRA Study
|
Phase 3 | |
| Terminated |
NCT02938078 -
Ocular Comfort and Inflammation in Lid Hygiene Therapy
|
N/A | |
| Completed |
NCT01408082 -
Efficacy and Safety Study of a Steroid/Antibiotic Combination Eyedrop to Treat Non-Bacterial Blepharitis
|
Phase 3 | |
| Completed |
NCT01028027 -
Loteprednol and Tobramycin Versus Tobramycin and Dexamethasone, in the Treatment of Blepharokeratoconjunctivitis
|
Phase 3 | |
| Recruiting |
NCT04858113 -
Short-term Effects on Tear Film (Baby Shampoo vs Blephasol)
|
N/A | |
| Completed |
NCT00560703 -
Treatment of Patients With Blepharitis and Facial Rosacea
|
Phase 2 | |
| Recruiting |
NCT02455895 -
Efficacy of iLid Cleanser (Avenova) Versus Vehicle on Ocular Skin Flora
|
N/A | |
| Completed |
NCT00894530 -
The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Four-Week Treatment Period (P08638)
|
Phase 2 | |
| Completed |
NCT01115192 -
Blephacura Versus Baby Shampoo to Treat Blepharitis
|
N/A | |
| Completed |
NCT02386774 -
Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa
|
N/A | |
| Completed |
NCT01808560 -
Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery
|
N/A | |
| Completed |
NCT01089608 -
Efficacy and Safety Assessment of Azyter® Eye Drops (T1225) in Patients With Blepharitis
|
Phase 2 | |
| Completed |
NCT00629590 -
Safety and Efficacy Pilot Study of AzaSite (Azithromycin) in Subjects With Blepharitis
|
Phase 4 | |
| Completed |
NCT00629941 -
Safety and Efficacy Study of AzaSite® in Subjects With Blepharitis
|
Phase 4 | |
| Completed |
NCT03926026 -
Study Evaluating the Safety and Tolerability of NCX 4251 for the Treatment of Acute Exacerbations of Blepharitis
|
Phase 2 | |
| Recruiting |
NCT04603222 -
Evaluation of SUMMIT BRUSH in Treatment of Blepharitis
|
N/A | |
| Completed |
NCT02218489 -
Safety and Efficacy of KPI-121 in Subjects With Inflammatory Meibomian Gland Disease
|
Phase 2 | |
| Completed |
NCT00796926 -
Trial to Compare the Efficacy of Systane Ultra and Refresh Drop in the Treatment of Dry Eye in Asian Eyes
|
Phase 3 |