Bleeding Clinical Trial
Official title:
Tranexamic Acid Contribution in the Prevention of Perioperative Bleeding in Pulmonary Resection Surgery
Bleeding after thoracic surgery is a major cause of perioperative hemodynamic instability and
transfusion requirement, which can lead to a rise of morbidity, mortality and costs.
The objective of this study is to evaluate the efficiency of tranexamic acid (TA) in the
prevention of perioperative bleeding in thoracic hemorrhagic surgery.
It's a randomized, double-blind, prospective study including patients over the age of 18
years old, programmed for potentially hemorrhagic thoracic surgery, such as pulmonary
resection for aspergilloma, pulmonary tuberculosis, pleural decortication, lobectomy with
parietectomy or redux. Demographic, clinical, biological data as well as transfusion
requirements, blood loss and perioperative complications were identified.
Two groups of patients:
- TA group: receiving tranexamic acid (25mg/kg) in bolus at induction followed by 2mg/kg/h
in continuous infusion until the end of the act.
- Serum saline isotonic (SSI) group: placebo with isotonic saline serum.
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