Bladder Dysfunction Clinical Trial
Compare the effectiveness of bethanechol chloride and early bladder training for prevention of bladder dysfunction after radical hysterectomy in cervical cancer stage IB - IIA.
Cervical cancer is the third most common cancer in women worldwide, after breast and colorectal cancer. Molecular biology has firmly established a causal relationship between persistent infection with high risk human papilloma virus (HPV) genotypes and cervical cancer. Cervical cancer stage IB1 and selected IIA 1 lesions without extensive vaginal involvement can be treated with either RH and pelvic lymph node dissection (PLD) or primary chemoradiation. Bladder dysfunction is the most common complication after radical hysterectomy. The incidence is approximate 10-80 %. Management of bladder dysfunction is continuous urethral catheterization or clean intermittent self-catheterization. Prolonged urethral catheterization may increase the risk of urinary tract infection. Early postoperative bladder training that consist of a scheduled clamping trans-urethral catheter every 3 h and unclamping trans-urethral catheter 15 min during the entire day. Bethanechol chloride is a cholinergic drug and may enhance the detrusor muscle contraction, resulting in higher maximum flow rate, and lower postvoid residual urine. This study was conducted to compare the effectiveness of bethanechol chloride and early bladder training for prevention of bladder dysfunction after radical hysterectomy in cervical cancer stage IB - IIA. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT00713921 -
Neuropathic Investigation and Anticholinergic Treatment of Bladder Dysfunction in Diabetes and Stroke Patients
|
Early Phase 1 | |
| Withdrawn |
NCT00472784 -
Quantitative and Qualitative Changes in Neural Efferent Receptors
|
||
| Completed |
NCT04528784 -
Feasibility Study of Transcutaneous Tibial Nerve Stimulation for Urinary Symptoms in People With Multiple Sclerosis
|
N/A | |
| Terminated |
NCT00688948 -
Alfuzosin for Voiding Dysfunction in Multiple Sclerosis (MS)
|
Phase 2/Phase 3 | |
| Completed |
NCT05858840 -
Urinary Artificial Sphincter in Children
|
||
| Recruiting |
NCT05968352 -
Restoration of Bladder Function in Spinal Cord Injury
|
||
| Recruiting |
NCT05462561 -
Vascularized Composite Bladder Allograft Transplantation
|
N/A | |
| Completed |
NCT05013541 -
Effect of Bladder Filling on Rectal Contractions During Cystometry
|
||
| Recruiting |
NCT04993859 -
Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children
|
||
| Recruiting |
NCT04626167 -
Concomitant Renal and Urinary Bladder Allograft Transplantation
|
Early Phase 1 | |
| Completed |
NCT03570593 -
Removal of Urinary Catheter After Radical Surgery
|
N/A | |
| Active, not recruiting |
NCT04490642 -
Linguistic Validation of the Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) for 5-12 Years Old in Korean
|
||
| Completed |
NCT04057222 -
Effect of Need to Void on Rectal Sensory Function in Multiple Sclerosis
|
||
| Recruiting |
NCT04835766 -
Urodynamic Changes Following Bladder Injury
|
||
| Completed |
NCT05351138 -
Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy
|
N/A | |
| Completed |
NCT03987126 -
Prebiotics for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction
|
Phase 3 | |
| Completed |
NCT01460303 -
Patient-operated Valved Catheter Versus Indwelling Transurethral Catheter
|
N/A | |
| Completed |
NCT00280592 -
Cranberry for Prevention of Urinary Tract Infections in Multiple Sclerosis Patients
|
Phase 3 | |
| Completed |
NCT05861011 -
Bladder Neck Surgery in Children With Neurogenic Bladder
|
||
| Completed |
NCT04134104 -
Incidence of The Bowel, Bladder, and Sexual Dysfunction Following Surgery for Colorectal Malignancy
|