Effect of Fresh Gas Flow on Emergence Time

Bladder Cancer Clinical Trial

Official title:

Effect of Fresh Gas Flow on Emergence Time in the Patients Undergoing Transurethral Resection of Bladder Tumor: A Randomized Controlled Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05376631
• Other study ID #: 2022-0606
• Status: Completed
• Phase: N/A
• Start date: May 20, 2022
• Est. completion date: August 17, 2022

Study information

• Verified date: August 2022
• Source: Asan Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the effect of fresh gas flow on emergence time in patients undergoing transurethral resection of bladder tumor.

Description:

The purpose of this study is to evaluate the effect of fresh gas flow (5 L/min vs. 10 L/min) on emergence time in patients undergoing transurethral resection of bladder tumor.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 54
• Est. completion date: August 17, 2022
• Est. primary completion date: August 16, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 79 Years

Eligibility

Inclusion Criteria:

• Patients who are scheduled transurethral resection of bladder tumor under general anesthesia
• Patients aged between 20 and 79 years old
• American Society of Anesthesiologists physical status =2
• Patients who are voluntarily agreed to this clinical study

Exclusion Criteria:

• A long operation (2 hours or longer)
• Hearing disturbance
• Cognitive disorder
• Psychiatric substance abuse
• Patient's denial

Related Conditions & MeSH terms

• Bladder Cancer
• Urinary Bladder Neoplasms

Intervention

Procedure:
• Fresh gas flow of 5 L/min
A fresh gas flow of 5 L/min is used during emergence from general anesthesia.
• Fresh gas flow of 10 L/min
A fresh gas flow of 10 L/min is used during emergence from general anesthesia.

Locations

Country	Name	City	State
Korea, Republic of	Asan Medical Center	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Asan Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (5)

Baum JA. Low-flow anesthesia: theory, practice, technical preconditions, advantages, and foreign gas accumulation. J Anesth. 1999;13(3):166-74. — View Citation

Brioni JD, Varughese S, Ahmed R, Bein B. A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics. J Anesth. 2017 Oct;31(5):764-778. doi: 10.1007/s00540-017-2375-6. Epub 2017 Jun 5. Review. — View Citation

Difficult Airway Society Extubation Guidelines Group, Popat M, Mitchell V, Dravid R, Patel A, Swampillai C, Higgs A. Difficult Airway Society Guidelines for the management of tracheal extubation. Anaesthesia. 2012 Mar;67(3):318-40. doi: 10.1111/j.1365-2044.2012.07075.x. — View Citation

Gaya da Costa M, Kalmar AF, Struys MMRF. Inhaled Anesthetics: Environmental Role, Occupational Risk, and Clinical Use. J Clin Med. 2021 Mar 22;10(6). pii: 1306. doi: 10.3390/jcm10061306. Review. — View Citation

Sakata DJ, Gopalakrishnan NA, Orr JA, White JL, Westenskow DR. Hypercapnic hyperventilation shortens emergence time from isoflurane anesthesia. Anesth Analg. 2007 Mar;104(3):587-91. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Emergence time	When consciousness and self respiration are fully recovered after surgery is ended, extubation is tried. The time to extubation (emergence time) is recorded.	From end of surgery to extubation (assessed up to 30 minutes after surgery)
Secondary	Time to spontaneous movement	After surgery is stopped, the patients are asked to open their eyes every 1 minute after the termination of sevoflurane administration. The time to spontaneous movement is recorded.	From end of surgery to spontaneous movement (assessed up to 30 minutes after surgery)
Secondary	Time to eye opening	After surgery is stopped, the patients are asked to open their eyes every 1 minute after the termination of sevoflurane administration. The time to eye opening is recorded.	From end of surgery to eye opening (assessed up to 30 minutes after surgery)