Mapping 3D Bladder

Bladder Cancer Clinical Trial

Official title:

Feasibility of Spatially Registered Endoscopy for Mapping Bladder Mucosal Disease Into Radiation Planning Morphologic Imaging

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT05260788
• Other study ID #: 21-5338
• Status: Withdrawn
• Start date: March 2022
• Est. completion date: March 2025

Study information

• Verified date: April 2022
• Source: University Health Network, Toronto
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This is a single centre, single arm feasibility study assessing the feasibility of using computer vision methods to recreate the 3D bladder shape and to then map the cystoscopy images onto this bladder shape. If feasible, this 3D reconstructed shape would be spatially registered to radiological images (CT, MR) that are then used during radiation treatment planning. This analysis would not be used for making any clinical treatment decisions on the patient.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: March 2025
• Est. primary completion date: March 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria:

• 18 years of age or older.

• Clinical suspicion or histologic diagnosis of bladder tumour suitable for endoscopic evaluation.

• Intention to treat using external beam radiation therapy as part of standard of care.

• Ability to provide written informed consent to participate in the study.

Exclusion Criteria:

• Prior complete or partial radiation therapy to bladder.

• Contraindications to radiation therapy as determined by the treating physician.

• Concurrent illness or condition that precludes subject from undergoing endoscopy or CT scanning.

Related Conditions & MeSH terms

• Bladder Cancer
• Urinary Bladder Neoplasms

Intervention

Procedure:
• Cystoscopy
Standard of care cystoscopy procedure

Locations

Country	Name	City	State
Canada	Princess Margaret Cancer Centre	Toronto	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
University Health Network, Toronto

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Video recording of Cystoscopy	To determine the feasibility of using bladder endoscopic video images to reconstruct the three-dimensional shape of the bladder based on computer visions methods that employ feature extraction and triangulation and to map the endoscopy images onto the recreated 3D surface.	At study completion, up to 2 years
Primary	Contouring of 3D bladder rendering	To determine the feasibility of contouring the mucosal disease on the 3D bladder rendering.	At study completion, up to 2 years
Primary	Registering bladder shape	To determine the feasibility of registering the bladder shape to a CT/MR scan of the patient using deformable shape methods.	At study completion, up to 2 years