| Eligibility |
Master Protocol Inclusion Criteria:
1. Capable of giving signed informed consent which includes compliance with the
requirements and restrictions listed in the informed consent form (ICF) and in this
protocol.
2. Age = 18 years of age at the time of signing the informed consent.
3. Prior CDC-recommended vaccination series against PV and has received a boost
immunization with trivalent Poliovirus Vaccine Inactivated (IPOL®) (Sanofi-Pasteur SA)
at least 1 week, but less than 6 weeks, prior to Cycle 1 Day 1.
* Note: Patients who are unsure of their vaccination status must provide evidence of
anti-PV immunity prior to enrollment, as applicable.
4. Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.
5. A formalin-fixed paraffin-embedded (FFPE) tumor specimen (from archival or fresh
biopsy) with an associated pathology report documenting the histology of the tumor
type of interest must be confirmed to be available to send to the Sponsor.
* Note: additional details can be found in the tumor specific appendix.
6. Eastern Cooperative Oncology Group (ECOG) status of 0 or 1.
7. Adequate bone marrow and liver function as assessed by the following:
- Hemoglobin =9.0 g/dl (patients may be transfused)
- Lymphocyte count = 0.5 x 109/L (500/µL)
- Absolute neutrophil count (ANC) =1.5 x 109/L (1500/µL)
- Platelet count =100 x 109/L (100,000/µL) without transfusion
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) = 2.5 x upper
limit of normal (ULN)
- Subjects with documented liver metastases: AST and ALT =5 x ULN
- Serum total bilirubin =1.5 x ULN OR direct bilirubin <ULN for patients with total
bilirubin > 1.5 x ULN
- For patients not receiving therapeutic anticoagulation: international normalized
ratio (INR), prothrombin time (PT), partial thromboplastin time (PTT) (or
activated partial thromboplastin time [aPTT]) = 1.5 x ULN
8. Resolution of nonhematologic toxicities from prior therapy or surgical procedures to
= Grade 1 or baseline (except alopecia).
9. Contraceptive use by men or women of childbearing potential should be consistent with
local regulations regarding the methods of contraception for those participating in
clinical studies.
Master Protocol Exclusion Criteria:
1. Any radiotherapy, chemotherapy, immunotherapy, biological, investigational, or
hormonal therapy for cancer treatment (except for adjuvant hormonal therapy for breast
cancer or prostate cancer defined as M0 disease or prostate-specific antigen
persistence/recurrence without metastatic disease) within 21 days of Cycle 1 Day 1.
2. Patients requiring anticoagulation with warfarin are excluded. Additional eligibility
criteria for anticoagulation requirements for each solid tumor cancer of interest will
be provided in the tumor specific appendix.
3. Presence of central nervous system (CNS) metastases requiring immediate treatment with
radiation therapy or steroids (ie, patient must be off steroids administered for brain
metastases for = 14 days prior to Cycle Day 1). Leptomeningeal disease is excluded
regardless of clinical stability or treatment status.
4. Clinically significant (ie, active) cardiovascular disease at the time of signing the
informed consent; for example, cerebrovascular accidents (= 6 months before the first
dose of lerapolturev, myocardial infarction (= 6 months before the first dose of
lerapolturev), unstable angina, serious cardiac arrythmia requiring medication, or
uncontrolled symptomatic congestive heart failure [Class II or higher as defined by
the New York Heart Association [NYHA] functional classification system; see Appendix
4]).
5. QTcF interval > 450 msec (males) or > 470 msec (females) at Screening (confirmed in
triplicate). For patients with ventricular pacemakers or bundle branch block, QTcF
>500 msec.
6. Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
prior to Cycle Day 1, or anticipation of the need for major surgical procedure during
the course of the study.
7. Active or history of autoimmune disease or immune deficiency within previous 2 years,
with the following exceptions:
- History of autoimmune-related hypothyroidism that is managed by thyroid
replacement hormone
- Type 1 diabetes mellitus that is well-controlled (as determined by the
Investigator) by an established insulin regimen
- Eczema, psoriasis, or lichen simplex chronicus with dermatologic manifestations
only (eg, patients with psoriatic arthritis are excluded), provided all of the
following conditions are met:
- Rash must cover < 10% of body surface area
- Disease is well-controlled (as determined by the Investigator) at baseline
and requires only low-potency topical corticosteroids
- No occurrence of acute exacerbations of the underlying condition requiring
psoralen plus ultraviolet A radiation, methotrexate, retinoids, biologic
agents, oral calcineurin inhibitors, or high potency or oral corticosteroids
within 12 months of Cycle 1 Day 1
8. History of idiopathic pulmonary fibrosis, organizing pneumonia (eg, bronchiolitis
obliterans), drug-induced or idiopathic pneumonitis, or evidence of active pneumonitis
on screening chest computed tomography (CT) scan.
- History of radiation pneumonitis in the radiation field (fibrosis) is allowed.
9. Uncontrolled pleural effusion, pericardial effusion, or ascites; patients with
indwelling catheters (eg, PleurX®) are allowed.
10. Known serious active infection (eg, human immunodeficiency virus [HIV], hepatitis B or
C, tuberculosis, etc.).
- Participants with a negative hepatitis B surface antigen (HBsAg) test and a
positive total hepatitis B core antibody (HBcAb) test are allowed.
- History of positive hepatitis C virus (HCV) antibody test, but negative HCV RNA
test is allowed.
- Participants with a historical positive HIV test are not allowed.
11. Treatment with systemic immunosuppressive medication within 28 days of Cycle 1 Day 1,
with the following exceptions:
- Patients who received acute, low-dose systemic immunosuppressant medication or a
one-time pulse dose of systemic immunosuppressant medication (eg, 48 hours of
corticosteroids for a contrast allergy) are eligible.
- Patients receiving mineralocorticoids (eg, fludrocortisone), or systemic
prednisone equivalent corticosteroid doses of < 10 mg per day are eligible for
the study.
12. Prior allogeneic or autologous hematopoietic stem cell or bone marrow transplantation.
13. Receipt of any live, attenuated vaccines within 28 days of Cycle 1 Day 1. Vaccination
to prevent symptomatic SARS-CoV-2 infection is allowed as long as the vaccine is NOT a
live attenuated vaccine (e.g. adenovirus-based constructs); however, the vaccine
should be administered = 1 week before or after a lerapolturev injection.
14. Known hypersensitivity to any of the drugs used in this study.
15. Pregnant or lactating women.
16. History of human serum albumin allergy.
17. History of neurological complications due to PV infection.
18. History of agammaglobulinemia.
19. Legal incapacity or limited legal capacity.
20. Other uncontrolled serious chronic disease or psychiatric condition that in the
Investigator's opinion could affect the patient's safety, compliance, or follow-up in
the protocol.
Non-Muscle Invasive Bladder Cancer Specific Inclusion Criteria:
1. Prior history of stage Ta, T1, or Tis urothelial carcinoma of the bladder
1. Tumors with up to 50% squamous or glandular differentiation are eligible
2. History of variant bladder histologies are excluded (eg, sarcomatoid,
plasmacytoid, small cell or neuroendocrine, pure pure squamous cell carcinoma,
pureadenocarcinoma, micropapillary, nested, lymphepithelioma-like, clear cell)
2. Documented tumor recurrence at cystoscopy where the tumor is amenable to TURBT or
cystectomy.
3. Measured or calculated (per institutional standard) creatinine clearance = 45 ml/min
(glomerular filtration rate [GFR] can also be used in place of creatinine clearance).
4. If the patient has an available formalin-fixed paraffin-embedded (FFPE) tumor specimen
with an associated pathology report documenting NMIBC, the specimen must be confirmed
to be available to send to the Sponsor. Patients without an available FFPE specimen
are still eligible to enroll.
5. Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 is
NOT required. This is an exception to the inclusion criterion outlined in the master
protocol.
Non-Muscle Invasive Bladder Cancer Specific Exclusion Criteria:
1. Patients with exposure to intravesical agents (e.g. BCG, mitomycin C, epirubicin,
oncolytic viruses, anti-PD-1/L1 inhibitors, investigational therapies, etc.) within 3
months prior to the administration of lerapolturev.
2. Patients whose anticoagulation or antiplatelet medications cannot be managed by local
institutional guidelines to accommodate the safe intravesical instillation of
lerapolturev followed by TURBT, as determined by the treating physician.
3. Received prior radiation to the pelvis.
4. Received prior systemic therapy for bladder cancer, including PD-1/L1 inhibitors.
5. History of vesicoureteric reflux or an indwelling urinary stent.
6. History of stage T2 or higher bladder cancer
7. Medical conditions (as determined by the investigator) that would interfere with the
ability of the patient to retain urine for 2 hours. Examples include urinary
incontinence, overactive bladder, or low bladder compliance.
|
