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Radiation and Durvalumab Immunotherapy As Neoadjuvant Treatment for MIBC — RADIANT  

Bladder Cancer Clinical Trial

Official title:
Neoadjuvant Immune-Modulating Radiation With Durvalumab (MEDI4736) Prior to Radical Cystectomy in Patients With Muscle-Invasive Bladder Carcinoma (RADIANT)

Clinical Trial Summary

This study assesses the effect of sequential radiation and durvalumab immunotherapy given as treatment prior to surgery with radical cystectomy for bladder cancer.

Clinical Trial Description

In this phase II study, patients who are either not eligible or declined to have chemotherapy prior to surgery for muscle-invasive bladder cancer may consent and enrol to study. Patients will have single 8 Gy hypofractionated radiation to bladder followed by 3 cycles of durvalumab immunotherapy prior to radical cystectomy. This study will assess the safety and tolerability, pathological and radiological response, and immune biological correlatives to understand the effect of radiation and durvalumab. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04543110
Study type Interventional
Source Ottawa Hospital Research Institute
Contact Michael Ong, MD
Phone 613-737-7700
Email mong@toh.ca
Status Recruiting
Phase Phase 2
Start date January 29, 2021
Completion date November 2024
View Details
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