Influence of Opioids on Circulating Tumor Cells in Radical Cystectomy

Status Completed

Clinical Trial Summary

Multiple lines of evidence have shown that perioperative opioids requirement was associated with poor outcomes in cancer patients, including increased cancer progression and metastases and reduced survival in patients with lung, breast, prostate, and bladder cancer. Circulating tumor cells (CTCs) have been validated as prognostic biomarkers of a number of cancers. The aim of this study is to investigate the effects of perioperative opioids on the number of CTCs in patients receiving robot-assisted laparoscopic radical cystectomy. The difference of the amounts of perioperative opioids is achieved by using general anesthesia combined with intravenous opioid-based analgesia intra- and post-operatively in one group and general analgesia combined with epidural ropivacaine-based analgesia in the other group.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04358718
Study type	Interventional
Source	RenJi Hospital
Contact
Status	Completed
Phase	N/A
Start date	June 2, 2020
Completion date	January 21, 2021

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT06034015` - A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of APL-1501 Extended Release (ER) Capsules Compared to APL-1202 Immediate Release (IR) Tablets in Healthy Volunteers	Phase 1
Recruiting	`NCT04235764` - En-bloc Transurethral Resection of Bladder Tumor (En-bloc TURBT) Specimens Using a Redesigned Surgical Resectoscope Device
Completed	`NCT02371447` - VPM1002BC in Recurrent Non-muscle Invasive Bladder Cancer	Phase 1/Phase 2
Recruiting	`NCT04081246` - Transurethral Modified En Bloc Resection For Large Bladder Tumours.	N/A
Recruiting	`NCT06059547` - Neoadjuvant Immunotherapy in Combination With the Anti-GDF-15 Antibody Visugromab (CTL-002) for Treatment of Muscle Invasive Bladder Cancer	Phase 2
Terminated	`NCT04779489` - Checkpoint Inhibitor and Radiation Therapy in Bulky, Node-Positive Bladder Cancer	N/A
Not yet recruiting	`NCT04493489` - Propranolol Adjuvant Treatment of Bladder Cancer	Phase 2
Completed	`NCT03520231` - Study Comparing Denosumab With Standard Treatment in Urothelial Cancer Patients With Bone Metastases	Phase 2
Recruiting	`NCT04537221` - Nordic Cystectomy Study III - Transfusion
Withdrawn	`NCT03007771` - Magnetic Resonance-guided High-Intensity Focused Ultrasound (MR-HIFU) Used for Mild Hyperthermia	Phase 1
Completed	`NCT01955408` - Severity of Overactive Bladder Symptoms in Patients After Synergo Treatment	N/A
Completed	`NCT04487457` - Prospective Study to Evaluate the Blood Kinetics of Immune Cells and Immunosuppressive Cytokines After Exposure to an Immunity Checkpoint Inhibitor (ICI): Study of the Impact of Chemotherapy
Active, not recruiting	`NCT04383210` - Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors	Phase 2
Recruiting	`NCT05562791` - A Study of 68Gallium PSMA-PET/CT Scans in People With Bladder Cancer	Phase 1
Completed	`NCT00199849` - NY-ESO-1 Plasmid DNA (pPJV7611) Cancer Vaccine	Phase 1
Completed	`NCT02781428` - To Detect the Sensitivity of the UroMark Assay
Recruiting	`NCT04738630` - Study of HX008 for the Treatment of BCG-Unresponsive Non-muscle Invasive Bladder Cancer	Phase 2
Completed	`NCT03980041` - Study to Evaluate the Efficacy/Safety of IPI-549 in Combination With Nivolumab in Patients With Advanced Urothelial Carcinoma (MARIO-275)	Phase 2
Active, not recruiting	`NCT03978624` - Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer	Phase 2
Completed	`NCT04534309` - Behavioral Weight Loss Program for Cancer Survivors in Maryland	N/A