Birth Control Clinical Trial
Official title:
The Effect of Tubal Ligation, Essure Placement, AND Levonorgestrel Intrauterine Device on Serum Anti-Mullerian Hormone Rates Over Time
Anti-mullerian hormone (AMH) has been shown to be a reliable marker of ovarian reserve. In prior studies, tubal ligation has been shown to have an adverse effect on ovarian reserve. One theory postulated for this effect is that the ovarian circulation is disrupted by the procedure, leading to altered hormone production. In this prospective cohort study, the investigators plan to analyze the rates of AMH decline by comparing the following contraceptive methods: tubal ligation, Essure placement, and levonorgestrel intrauterine devices (IUDs).
Anti-mullerian hormone (AMH) has been shown to be a reliable marker of ovarian reserve
because levels demonstrate a consistent age-related decline and do not fluctuate throughout
the menstrual cycle. In prior studies measuring markers other than AMH, tubal ligation has
been shown to have an adverse effect on ovarian reserve.
The primary aim of this study will be to compare the rates of anti-mullerian hormone (AMH)
decline following tubal ligation, Essure placement, and levonorgestrel IUDs, and then
identifying any and all differences that these specific contraceptive methods have on the
changes of AMH rates over time. The secondary aim will focus on analyzing the various types
of tubal ligation methods (i.e. coagulation, ligation, clips, bands, etc.) to see if
different techniques result in any difference in the rate of AMH decline. The hypothesis is
that tubal ligation will result in an accelerated rate of AMH decline as compared to other
long-term or permanent contraceptive methods.
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Observational Model: Case Control, Time Perspective: Prospective
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