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Bipolar Disorders clinical trials

View clinical trials related to Bipolar Disorders.

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NCT ID: NCT00891826 Completed - Bipolar Disorders Clinical Trials

Omega-3 Fatty Acids in Bipolar Patients With a Low Omega-3 Index and Reduced Heart Rate Variability

Start date: April 2009
Phase: N/A
Study type: Interventional

This study sets out to test the hypothesis that parameters of heart rate variability, as a non-invasive measure of cardiovascular risk, can be improved by the addition of omega-3 fatty acids in euthymic bipolar patients with a low omega-3 index and reduced heart rate variability.

NCT ID: NCT00888264 Completed - Bipolar Disorders Clinical Trials

A NIS Evaluating the Treatment Patterns of Atypical Antipsychotics in Patients Diagnosed With Bipolar I or II Disorder

HARMONY
Start date: May 2009
Phase: N/A
Study type: Observational

The purpose of this NIS is to obtain data on how AAPs are used in DSM-IV-TR Bipolar I and II Disorder, in the course of a major depressive episode. Both the parameters of use of AAPs and clinical evaluation will be recorded and potential differences that may exist due to epidemiological factors or comorbidities will be analyzed.

NCT ID: NCT00845988 Completed - Bipolar Disorders Clinical Trials

Metabolic Effects of Switching to Aripiprazole in Patients With Bipolar Disorders

Start date: December 2008
Phase: Phase 4
Study type: Interventional

The primary goal of this study is to investigate metabolic changes and maintaining efficacy in stabilized patients with bipolar disorders who have pharmacologically induced weight gain.

NCT ID: NCT00453804 Completed - Schizophrenia Clinical Trials

Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI)

vivitrol
Start date: July 2006
Phase: Phase 4
Study type: Interventional

The primary aim of this study is to determine the feasibility of long-acting injectable naltrexone administration in a clinical trial in patients with SMI who also have a diagnosis of alcohol dependence. Secondary aims include providing a preliminary assessment of the tolerability and safety of long-acting injectable naltrexone as compared with oral naltrexone in patients with SMI who also have a diagnosis of alcohol dependence. An additional aim is to provide a preliminary assessment of the efficacy of long-acting injectable naltrexone as compared with oral naltrexone in reducing alcohol use from baseline levels

NCT ID: NCT00257075 Completed - Bipolar Disorders Clinical Trials

A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Manic Episodes Associated With Bipolar I Disorder

Start date: December 2000
Phase: Phase 3
Study type: Interventional

The purpose of the study is to assess the effectiveness and safety of risperidone (an antipsychotic medication) versus placebo during 3 weeks of treatment of mania in patients with Bipolar I Disorder who are suffering a manic episode.

NCT ID: NCT00253162 Completed - Bipolar Disorders Clinical Trials

A Study of the Effectiveness and Safety of Risperidone Compared With Placebo in the Treatment of Manic Episodes Associated With Bipolar I Disorder, and the Maintenance of Anti-manic Effectiveness of Risperidone Compared With Haloperidol

Start date: March 2001
Phase: Phase 3
Study type: Interventional

The purpose of the study is to assess the effectiveness and safety of risperidone (an antipsychotic medication) compared with placebo after 3 weeks of treatment in patients with bipolar disorder who are experiencing manic episodes. A secondary purpose of the study is to assess the maintenance of risperidone effectiveness versus haloperidol (an antipsychotic medication) after 12 weeks of treatment.

NCT ID: NCT00253149 Completed - Bipolar Disorders Clinical Trials

A Study of the Effectiveness and Safety of Risperidone as add-on Therapy to Mood Stabilizers in the Treatment of Manic Episodes Associated With Bipolar Disorder

Start date: n/a
Phase: Phase 3
Study type: Interventional

The purpose of the study is to evaluate the effectiveness and safety of risperidone (an antipsychotic medication) versus placebo as add-on therapy to mood stabilizers in the treatment of manic episodes associated with bipolar disorder.

NCT ID: NCT00240721 Completed - Mood Disorders Clinical Trials

A Study of the Effectiveness and Safety of Topiramate in the Treatment of Patients With Bipolar Disorder

Start date: October 2000
Phase: Phase 3
Study type: Interventional

The primary purpose of this study is to evaluate the effectiveness and safety of topiramate compared with placebo in the treatment of acute manic or mixed episodes in patients with Bipolar I Disorder.

NCT ID: NCT00156325 Completed - Bipolar Disorders Clinical Trials

Escitalopram as a Mood Stabilizer for Bipolar II Disorder

Start date: February 2004
Phase: Phase 2
Study type: Interventional

This study will investigate the efficacy of Escitalopram, a Selective Serotonin Reuptake Inhibitor (SSRI) antidepressant, in the treatment of Bipolar II Disorder. The use of antidepressants for those with bipolar disorder appears common in clinical practice but is not countenanced - at least as monotherapy - in formal treatment guidelines. This view reflects concerns about the possibility of antidepressant drugs inducing switching and rapid cycling in those with Bipolar Disorder. Although the effectiveness of treating Bipolar II patients with SSRIs has received very little attention in the literature, observations of Bipolar II patients treated with SSRIs suggest they may have general mood stabilising properties. Many patients have reported improvements not only in their depressed mood, but also a reduction in the severity, duration and frequency of hypomanic episodes. In this proof of concept study we specifically assess whether a standard dose of an SSRI antidepressant is more effective than placebo in reducing the frequency, severity and duration of both depressive and hypomanic episodes.