Magnetic Seizure Therapy vs. Electroconvulsive Therapy for Bipolar Mania

Bipolar Disorder, Manic Clinical Trial

Official title: Magnetic Seizure Therapy vs. Electroconvulsive Therapy for Bipolar Mania

Status Withdrawn

Clinical Trial Summary

This trial attempts to evaluate the treatment efficacy of magnetic seizure therapy (MST) and its safety for bipolar mania. Half of the participants will receive MST, while the other half will receive electroconvulsive therapy (ECT).

Clinical Trial Description

Magnetic seizure therapy (MST) is likely to be an alternative options to electroconvulsive therapy (ECT).

Widespread stimulation of cortical and subcortical regions is inevitable for ECT since the substantial impedance of the scalp and skull shuts most of the electrical stimulus away from the brain. Nevertheless, magnetic pulses are capable to focus the stimulus to a specific area of the brain because they can pass the scalp and skull without resistance. In Addition, electric current will penetrate into deeper structures, while magnetic stimulus are only capable to reach a depth of a few centimeters. As a consequence, MST are able to generate focus stimuli on superficial regions of the cortex while ECT can't, which may give MST the capability to produce comparable therapeutic benefits with the absence of apparent cognitive side effects. ;

Related Conditions & MeSH terms

• Bipolar Disorder
• Bipolar Disorder, Manic
• Seizures

• NCT number: NCT03016104
• Study type: Interventional
• Source: Shanghai Mental Health Center
• Status: Withdrawn
• Phase: N/A
• Start date: November 2016
• Completion date: December 2017