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Bipolar Disorder (BD) clinical trials

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NCT ID: NCT05177146 Recruiting - Suicidality Clinical Trials

Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar Depression

DEEPP
Start date: May 4, 2022
Phase: N/A
Study type: Interventional

Bipolar disorder is characterized by manic episodes and episodes of extreme depressive feelings, also known as bipolar depression (BD). Although clinical data does not suggest significant differences in the severity of depressive symptoms between bipolar and unipolar depression, patients with BD are found to be more likely to experience suicidal ideation and suicide attempts. Innovative treatments for suicidality in patients with BD are needed to address tolerability and slow effect limitations of current interventions. Using an open label pilot study, this trial aims to examine the effect of Intravenous (IV) ketamine treatment on acute suicidality in patients with BD. Moreover, the study aims to explore the neurophysiological mechanisms of ketamine's action directly from the cortex in patients with BD, in order to understand the biological mechanism underlying ketamine's therapeutic action.