Translational Initiative to Map Epigenetics in Sleep

Biological Aging Clinical Trial

— TIME-ZZZ  

Official title:

Translational Initiative to Map Epigenetics in Sleep

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06333301
• Other study ID #: TIME-ZZZ
• Status: Not yet recruiting
• Start date: April 2024
• Est. completion date: April 2034

Study information

• Verified date: March 2024
• Source: Elysium Health
• Contact: Ryan W Dellinger, PhD
• Phone: 8882206436
• Email: care[@]elysiumhealth.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The primary aim of TIME-ZZZ is to explore the relationship between chronotype, incidence of depression and biological age, and whether individuals working "out-of-phase" with their chronotype are more likely to exhibit signs of depression and accelerated biological aging.

Description:

Understanding the relationship between chronotype, depression, and biological age is important in the field of sleep research and mental health. Sleep patterns and their alignment with an individual's internal body clock, or chronotype, have been increasingly recognized as influential factors in various aspects of well-being, including mental health and overall physiological aging. By conducting a study that investigates the potential correlation between chronotype, incidence of depression, and biological age, along with the impact of working "out-of-phase" with one's chronotype, the investigators can shed light on crucial aspects of sleep, mental health, and their interplay with biological aging.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 10000
• Est. completion date: April 2034
• Est. primary completion date: April 2034
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Has taken an INDEX test within the last 3 months

• Has registered at least 1 INDEX kit via the Elysium Health website

• Able and willing to provide digital consent to the RSCF, and the TIME-ZZZ Research Subject Consent Form

Exclusion Criteria:

• Consent to participate not given

Related Conditions & MeSH terms

• Biological Aging

Intervention

Other:
• Surveys
Group will complete several surveys

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Elysium Health	University of Oxford

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effect of being "out of phase" with chronotype on biological age	Determine whether individuals working "out-of-phase" with their chronotype (from TIME-ZZZ survey responses) exhibit higher rates of biological aging compared to those working within their chronotype	At baseline
Secondary	Effect of Chronotype Alignment and Depression Risk in Relation to Rate of Aging	Determine the effect of chronotype alignment and depression risk (from TIME-ZZZ surveys) on biological rate of aging	At baseline
Secondary	Identification of DNA methylation markers associated with chronotype	Identify specific DNA methylation markers associated with chronotype (from TIME-ZZZ surveys) thereby providing potential insights into the epigenetic regulation of sleep-wake patterns	At baseline
Secondary	Identification of DNA methylation markers associated with depression	Identify specific DNA methylation markers associated with depression (from TIME-ZZZ surveys) potentially shedding light on the underlying epigenetic mechanisms involved in the development and progression of depressive disorders.	At baseline