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Clinical Trial Summary

This trial aims to characterise the pharmacokinetic (PK) profile and estimate drug exposure from Atoguanil in comparison to Malarone®.

Clinical Trial Description

After being informed about the study and potential risks, all adult participants giving written informed consent will be screened within 30 days prior to entering the trial on Day -1 to determine eligibility for study entry. The trial will establish whether the PK profile of both atovaquone (ATV), proguanil (PG) and cycloguanil (CG) from Atoguanil is similar to Malarone® and whether exposure of ATV from Atoguanil indicates that at least a 2-fold reduction in ATV dose compared with Malarone® is feasible (i.e. that the bioavailability of ATV in Atoguanil is approximately double that of ATV in Malarone®). ;

Study Design

Related Conditions & MeSH terms

NCT number NCT04866602
Study type Interventional
Source Medicines for Malaria Venture
Contact Stephan Chalon, MD, PhD
Phone +41 22 555 0379
Email [email protected]
Status Not yet recruiting
Phase Phase 1
Start date July 2021
Completion date September 2021

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