Binge Drinking Clinical Trial
Official title:
Afferent Neurocardiac Signals, Cue Reactivity, and Cognitive Control
Conscious attempts to regulate alcohol use are often undermined by automatic attention and arousal processes activated by alcohol cues, as well as by diminished ability to inhibit in-the-moment behaviors. The current study will examine whether a brief behavioral intervention of slow breathing paced at a resonance frequency of the cardiovascular system can interrupt automatic alcohol cue reactivity and enhance cognitive control in binge drinkers. Results from the proposed study may provide new prevention and intervention targets to interrupt unhealthy drinking behaviors.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | April 30, 2023 |
Est. primary completion date | April 30, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - Must report at least 2 binge drinking episodes in the past month - Have normal or corrected-to-normal vision Exclusion Criteria: - History or presence of serious psychiatric disorders, neurological disorders, or head injury resulting in a loss of consciousness - Presence of any serious medical condition - Report of more than a few occasions (3-4) of illicit drug use, except for cannabis, in the preceding year |
Country | Name | City | State |
---|---|---|---|
United States | Rutgers, The State University of New Jersey | New Brunswick | New Jersey |
Lead Sponsor | Collaborator |
---|---|
Rutgers, The State University of New Jersey |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | N2 ERP amplitude (in microvolts) elicited from an Alcohol Cued Go/No-Go task | The N2 component (in microvolts) of the event-related potential occurring 250-350 ms after stimulus presentation at frontal and central electrode sites during an Alcohol Cued Go/No-Go task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart | |
Primary | N2pc ERP amplitude (in microvolts) elicited from a visual dot probe detection task | The N2pc component of the event-related potential occurring 200-275 ms after stimulus presentation at parietal and occipital electrode sites (ipsilateral minus contralateral hemisphere activity) during a modified visual dot probe detection task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart | |
Primary | P3b ERP amplitude (in microvolts) elicited from a picture-viewing task | The P3b component of the event-related potential occurring 300-600 ms after stimulus presentation at central and parietal electrode sites during a picture viewing task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart | |
Primary | N2 ERP latency (in milliseconds) elicited from an Alcohol Cued Go/No-Go task | The latency of the N2 component of the event-related potential from frontal and central electrode sites during a picture viewing task following a 5-minute course of resonance breathing compared to a low-demand control task. Latency will be determined using 50% area latency from a difference wave between task conditions | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart | |
Primary | N2pc ERP latency (in milliseconds) elicited from a visual dot probe detection task | The latency of the N2pc component of the event-related potential from parietal and occipital electrode sites during a visual dot probe detection task following a 5-minute course of resonance breathing compared to a low-demand control task. Latency will be determined using 50% area latency from a difference wave between task conditions | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart | |
Primary | P3b ERP latency (in milliseconds) elicited from a picture-viewing task | The latency of the P3b component of the event-related potential from central and parietal electrode sites during a picture viewing task following a 5-minute course of resonance breathing compared to a low-demand control task. Latency will be determined using 50% area latency from a difference wave between task conditions | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart | |
Primary | Task accuracy from the behavioral response during the Alcohol Cued Go/No-Go task | Task accuracy as a percentage of correct behavioral responses to the task during the Alcohol Cued Go/No-Go ERP task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart | |
Primary | Reaction time from the behavioral response during the Alcohol Cued Go/No-Go task | Reaction time for the correct behavioral responses to the task measured in milliseconds during the Alcohol Cued Go/No-Go ERP task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart | |
Primary | Task accuracy from the behavioral response during the visual dot probe detection task | Task accuracy as a percentage of correct behavioral responses to the task during the visual dot probe detection task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart | |
Primary | Reaction time from the behavioral response during the visual dot probe detection task | Reaction time for the correct behavioral responses to the task measured in milliseconds during the visual dot probe ERP task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart |
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