Alcohol & Innate Immunity

Status Completed

Clinical Trial Summary

Alcohol leads to a leaky gut and translocation of bacterial products. This may lead to inflammation and immune dysfunction as well as the typical hangover symptoms.

Clinical Trial Description

Alcohol binge drinking, defined as 5 or more drinks for men and 4 or more drinks for women at one time, is the most frequent form of alcohol consumption worldwide, especially in younger people. This drinking pattern is popular and leads to increased mortality and morbidity. Therefore binge drinking is a major public health issue. The behavioural and neurological consequences of binge drinking are well characterized.

Less is known about the systemic effects on the gut as the first organ in contact with alcohol. Chronic alcohol intake can lead to increased gut permeability, bacterial translocation and alterations in the gut microbiome in animal models. Recently bacterial translocation has been shown in healthy volunteers after a single alcohol binge. On immune cells, acute alcohol intake seems to have dichotomous effects. On the one hand immunosuppressive and anti-inflammatory effects have been described, however, alcohol induced liver injury is driven by pro-inflammatory reactions. These immune effects seem to be driven by endotoxin or other bacterial products via Toll-like receptors that are translocated to the circulation via a defective gut barrier. Immune effects of alcohol have also been linked to hangover symptoms after an alcohol binge.

Furthermore there is evidence that endotoxemia might also contributes to alcohol dependence by promoting prolonged and increased voluntary alcohol intake in mice. On the other hand mutant mice lacking important genes for immune responses exhibit decreased alcohol consumption. This indicates that immune signaling promotes alcohol consumption. Therefore it is tempting to speculate that increased gut permeability leading to increased bacterial translocation after an acute alcohol binge could promote the desire for further alcohol consumption.

The investigators aim to test in this pilot trial whether one alcohol binge damages gut barrier function, increases bacterial translocation and causes innate immune dysfunction. Furthermore the effect of glucose and fructose will be studied too. ;

Study Design

Related Conditions & MeSH terms

Binge Drinking

Clinical Trial Details

NCT number	NCT02568904
Study type	Observational
Source	Medical University of Graz
Contact
Status	Completed
Phase
Start date	December 2016
Completion date	February 22, 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04105725` - Balanced Lifestyle for Undergraduate Excellence - Mobile (Project BLUEM)	N/A
Recruiting	`NCT05491551` - Alcohol-ROC-Training	N/A
Completed	`NCT02064998` - Two Consecutive Randomized Controlled Trials Using Mobile Phone Applications for Risky Alcohol Use	N/A
Completed	`NCT02336204` - Alcohol Consumption Relation With Nutritional Knowledge and Body Weight	N/A
Not yet recruiting	`NCT06326099` - Brief Binge Eating and Drinking Online Intervention	N/A
Recruiting	`NCT05565989` - Alcohol Consumption, Intention Implementation and Mindfulness Meditation (ADUC-Volet 3 " Prevention ")	N/A
Completed	`NCT01125371` - Computerized Brief Alcohol Intervention (BI) for Binge Drinking HIV At-Risk and Infected Women	N/A
Recruiting	`NCT06084832` - Smartphone Application for University Students With Binge Drinking Behavior	N/A
Completed	`NCT04853628` - An Animation- Versus Text-based Computer-tailored Game Intervention to Prevent Alcohol Consumption in Adolescents	N/A
Completed	`NCT03449095` - Understanding Alcohol Reward in Social Context	N/A
Recruiting	`NCT05522075` - Reducing Blood Pressure in Mid-life Adult Binge Drinkers	N/A
Completed	`NCT03652675` - Understanding and Intervening With Heavy Drinking Among Patients With HIV and HCV	N/A
Completed	`NCT02842073` - An Open Label Trial of Bupropion and Naltrexone for Binge Drinking	Phase 2
Completed	`NCT03288896` - Alerta Alcohol. Web-based Computer-tailored Intervention for Binge-drinking Prevention in Spanish Adolescents	N/A
Active, not recruiting	`NCT03567434` - Alcohol and Neural Cardiovascular Control in Binge Drinkers	N/A
Recruiting	`NCT03224416` - Individual and Contextual Factors That Influence Sexual Decisions	N/A
Active, not recruiting	`NCT05882214` - Metabolic Changes Induced by NMN in Healthy Subjects With Acute Binge Drink	N/A
Completed	`NCT01546025` - Brief Alcohol Intervention for School-to-Work Transitions	N/A
Completed	`NCT01503255` - A Stage 2 Cognitive-behavioral Trial: Reduce Alcohol First in Kenya Intervention	Phase 1
Active, not recruiting	`NCT04585906` - My Pathway to Healing	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Alcohol and Innate Immunity

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms