Biliary Atresia Clinical Trial
Official title:
Analysis of Gut Microbiome and Liver Imaging Including Elasticity in Biliary Atresia Patients With Cholangitis for the Prediction of Disease Activity and Improvement of Outcome Using Fecal Microbiota Transplantation
The investigator will investigate the gut-microbiome and liver elasticity of the Biliary
Atresia (BA)-patients before and after Kasai operation. The data will be analyzed according
to their clinical outcomes including cholangitis to find out diagnostic makers, significantly
associated with the BA-phenotypes. The decision-making tree for the BA will be updated with
our data, which will strength the prognosis and prediction. The establishment of gut-liver
axis, featured by cholangitis and gut-microbiome will open new pathway to treat the BA using
fecal microbiota transplantation.
1. Analysis of gut-microbiome: The investigator will investigate the alteration of
gut-microbiome by restoration of bile flow at diagnosis, before and after Kasai
procedure. In case of cholangitis after Kasai operation, signature gut-microbiome will
be analyzed, which will lead to prevention of BA-patients from cholangitis via the
bacteria transplantation.
2. Analysis of elastography: In order to improve non-invasive diagnosis, The investigator
will investigate the alteration of liver elasticity and hepatic blood flow before and
after Kasai procedure as well as upon cholangitis and choledochal cyst. Those data will
be analyzed in parallel with serum biochemical markers to be associated with
pathophysiological events e.g., cholestasis, cholangitis and fibrosis.
n/a
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