Bile Leak Clinical Trial
Official title:
Efficacy of NHS-PEG (Pentaerythirol Polyethylene Glycol Ether Tetra-succinimidyl Glutarate) Coated Collagen Patch (Hemopatch®) for Prevention of Bile Leaks After Liver Resection
In liver surgery bile leaks are still a major cause of postoperative morbidity with the need
for additional diagnostic tests, additional interventions, prolonged hospital stay, mortality
and higher costs. Efforts to further reduce the rate of postoperative biliary morbidity are
therefore important.A new polyethylene glycol (PEG)-coated collagen pad (Hemopatch®) showed
faster and more sustained hemostasis, less blood loss, and lower hematoma formation than the
fibrin-coated collagen patch in an animal model. This might be attributed to an improved
tissue adherence of the PEG-coated pad. We hypothesize that this strong adherence to the
hepatic resection surface may also serve as a mechanical sealant of bile ducts thus
preventing biliary leakage.
To date, there exists no study including a sufficient number of patients to clarify whether
sealing of the hepatic resection surface with Hemopatch® can reduce the rate of biliary leaks
and data regarding the expected difference in the incidence of biliary complications are
lacking.
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