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Bicuspid Aortic Valve clinical trials

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NCT ID: NCT01756222 Recruiting - Clinical trials for Bicuspid Aortic Valve

Bicuspid Aortic Valve (BAV) Registry

BAV
Start date: April 2010
Phase:
Study type: Observational [Patient Registry]

The purpose of this registry is to gather information on patients with bicuspid aortic valve disease.

NCT ID: NCT01390181 Recruiting - Clinical trials for Thoracic Aortic Aneurysm

The Effect of Losartan in Bicuspid Aortic Valve Patients

Start date: September 2011
Phase: N/A
Study type: Interventional

The specific aims of this study are to: - Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in individuals with bicuspid aortic valve and ascending aortic or aortic sinus measurements >40mm. - Assess the effect on MMP levels during treatment with losartan, an angiotensin II receptor blocking agent. - In the setting of losartan therapy for one year, evaluate the response of MMP levels in these patients, and clinical outcomes including effects on aortic growth rate