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Beryllium Disease clinical trials

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NCT ID: NCT00111917 Terminated - Berylliosis Clinical Trials

Beryllium Infliximab Study: Clinical Interventional Trial

BISCIT
Start date: February 2005
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of this research study is to test the clinical effectiveness of a drug called infliximab (Remicade) in chronic beryllium disease (CBD). This drug may reduce tumor necrosis factor-alpha (TNF-a), which is associated with more severe disease and inflammation in the lung. Receiving infliximab may help with symptoms, and may improve clinical testing data normally ordered by your doctor, such as breathing tests. Baseline and follow-up testing will look for improvements in breathing tests (pulmonary function testing), exchange of oxygen in the lungs (exercise test), chest x ray, and lung inflammation.