The Changes of Urine Growth Factors Level

Benign Prostatic Hyperplasia Clinical Trial

Official title:

The Changes of Urine Growth Factors Level in Patients With Benigh Prostate Hyperplasia After Medical Treatment

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06282731
• Other study ID #: ECKIRB1020407
• Status: Completed
• Phase: Early Phase 1
• Start date: May 31, 2013
• Est. completion date: April 27, 2017

Study information

• Verified date: February 2024
• Source: En Chu Kong Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The Changes of Urine Growth Factors Level in Patients With Benigh Prostate Hyperplasia after medical treatment.

Description:

The prevalence of benign prostate hyperplasia, like medical illness such as hypertension, diabetes mellitus and stroke, increase by age. Benign prostate hyperplasia will cause bothersome lower urinary tract symptoms in the middle and aged male. Previous studies have showed that overactive bladder syndrome (urge, frequency, nocturia or urinary incontinence) has been considered as an important factor to predict successful treatment.

Urine nerve growth factor level, brain-derived neurotrophic factor and endothelium vascular growth factor have been proved as a simple and noninvasive biomarker for diagnosing overactive bladder. As a result, investigator will investigate the changes of these growth factors level in patients with benign prostate hyperplasia before and after three and six-months medical treatment. In addition, investigator can understand whether overactive bladder will have effects on successful medical treatment in patients with benign prostate hyperplasia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 74
• Est. completion date: April 27, 2017
• Est. primary completion date: September 1, 2016
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 50 Years to 80 Years

Eligibility

Inclusion Criteria:

• men with age 50~80 years old

• IPSS>12

• maximal flowrate 5~15ml/sec

• prostate size>20ml

• urine amount>150ml

• patient/family can sigh the inform concent

Exclusion Criteria:

• prostate cancer or suspected prostate cancer(PSA>4ng/ml)

• history of prostate surgery

• free of active urinary tract infection in past 6 months

• patient with any other serious disease considered by investigator not in the condition to enter trials

Related Conditions & MeSH terms

• Benign Prostatic Hyperplasia
• Hyperplasia
• Prostatic Hyperplasia

Intervention

Drug:
• Silodosin
Indications:Benign prostate hyperplasia

Locations

Country	Name	City	State
Taiwan	En Chu Kong Hospital	New Taipei City

Sponsors (1)

Lead Sponsor	Collaborator
En Chu Kong Hospital

Country where clinical trial is conducted

Taiwan, 

References & Publications (51)

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* Note: There are 51 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Urine growth factors level	Check Urine growth factors level after si xmonth	Six months after medical treatment
Primary	Urine growth factors level	Check Urine growth factors level after one month	One month after medical treatment
Secondary	Urine growth factors level	Check Urine growth factors level afterthree month	Three months after medical treatment