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Effects of Chronic Use of Doxazosin in Men With Benign Prostatic Hyperplasia

Benign Prostatic Hyperplasia Clinical Trial

Official title:
A Prospective Study for the Effects of Chronic Use of Doxazosin on Alpha 1-adrenergic Receptors in Men With Benign Prostatic Hyperplasia

Clinical Trial Summary

In this study, we investigate the changes of the expression of alpha adrenergic receptor in the prostate tissue during 2-yr medication period in the man with benign prostatic hyperplasia. And we also evaluate the efficacy and safety of 24 mo-treatment with doxazosin (4mg, 8mg)

Clinical Trial Description

To compare the expression of alpha-1 adrenergic receptors, we will use various methodologies such as

- Real-time RT-PCR

- Radioligand receptor binding

- Western blot

- Immunohistochemistry ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00730418
Study type Interventional
Source Samsung Medical Center
Contact
Status Completed
Phase N/A
Start date January 2007
Completion date March 2010
View Details
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