Benign Pigmented Lesions Clinical Trial
Official title:
The Comparison of Picosecond 532 and 1,064 Nanometers Laser and Q-switched Nd:YAG 532 and 1,064 Nanometers Laser in the Treatment of Benign Pigmented Lesions: A Randomized Controlled Trial
The objective of this study is to evaluate the efficacy and safety of picosecond 532 and 1,064 nanometers laser in the treatment of benign pigmented lesions compared with q-switched 532 and 1,064 nanometers laser.
Benign pigmented lesions can be divided into epidermal lesions such as freckles, lentigines,
solar lentigines or cafe au lait macules and dermal lesions such as Nevus of Ota or Hori's
nevus.
Q-switched 532 and 1064 nm lasers were reported to be safe and effective in the treatment of
these benign pigmented lesions. By using selective photothermolysis theory, both q-switched
532 and 1064 nm lasers target on melanin causes photomechanical destruction of the melanin.
However, the occurrence of post inflammatory hyperpigmentation (PIH) were reported
especially in patients with darker skin type.
Recently, picosecond 532, 755, 1064 nm laser was reported to treat benign pigmented lesions
effectively. With their ultra short pulse duration (picosecond domain), it is ideally
believed to be pure photomechanical effects without thermal injury to surrounding tissue. As
a result, the incident of PIH should be reduced.
The investigators then aimed to compared the efficacy and efficacy of different pulse
duration between nanosecond and picosecond laser in the treatment of benign pigmented
lesions.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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