Neuro-ultrasound Assessment in Behcet's Disease

Behcet Syndrome Clinical Trial

Official title:

The Effect of Behcet's Disease on Cerebrovascular Circulation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04738864
• Other study ID #: 17300548
• Status: Recruiting
• Phase: N/A
• Start date: March 2021
• Est. completion date: August 2021

Study information

• Verified date: February 2021
• Source: Assiut University
• Contact: Esraa A Talaat, lecturer
• Phone: 01003314717
• Email: Esraa_ahmed[@]aun.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Assessment of structural changes that occur in large extracranial and intracranial arteries in patients with Behcet's disease

Description:

Patients will be selected from Rheumatology and Rehabilitation inpatient and outpatient clinics in Assiute University Hospital Patients under 16 years old, patients with hyperlipidemia, hypertension, diabetes mellitus and all other risk factors affecting blood vessel intimal thickness will be excluded from the research. All patients and control groups underwent a complete extracranial and intracranial ultrasound assessment by 2 experienced neurovascular sonographers .The ultrasound examination was done at the Neurovascular Ultrasound Laboratory in the Neurology department, Assiut University hospitals using a color-coded duplex ultrasound device Philips HD5 (Philips Medical Systems, Nederland B.V.) for the carotid and vertebral arteries and for the intracranial arteries. Intimal medial thickness (IMT) of the common carotid artery (CCA), peak systolic velocities (PSVs) and end diastolic velocities (EDVs) were measured in the common, internal, and external carotid arteries (CCA, ICA, ECA) with L 3-12 MHz linear transducer probe and when stenosis was detected the velocities were measured at the maximally stenotic area. The intracranial arteries were evaluated in all patients with transcranial color-coded duplexsonography (TCCS) with the use of a low-frequency (2- to 5-MHz) phased-array probe through the transtemporal acoustic bone window. The middle cerebral artery (MCA), intracranial segment of vertebral artery (V4)and basilar artery (BA) were examined. Peak systolic velocity (PSV) and flow direction (antegrade or reversed) used for the diagnosis of any intracranial atherosclerotic disease (ICAD). The findings and the atherosclerotic changes in the extracranial and intracranial vessels were interpreted according to the internationally published data Data will be analyzed using the computer program SPSS

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: August 2021
• Est. primary completion date: June 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• patient more than 18 years old
• All patients fulfill the modified International Criteria for Behçet's Disease

Exclusion Criteria:

• Patients under 16 years old,
• patients with hyperlipidemia, hypertension, diabetes mellitus and all other risk factors affecting blood vessel intimal thickness

Related Conditions & MeSH terms

• Behcet Syndrome

Intervention

Diagnostic Test:
• ultrasound
extracranial and intracranial ultrasound assessment

Locations

Country	Name	City	State
Egypt	Medicine	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	CNS vascular involving	ultrasound of CNS vescle	6 mounth