Behcet Syndrome Clinical Trial
Official title:
Serum (PLR), (LMR), (MPV) and (NLR) in Behcet Disease and Their Correlation With Disease Activity
- To determine platelet to lymphocyte ratio (PLR), lymphocytes to monocytes ratio (LMR),
mean platelet volume (MPV) and neutrophile lymphocyte ratio (NLR), levels in Behçet's
disease (BD)
- To investigate their correlation with disease activity.
Behçet' s disease (BD) is a complex, inflammatory multisystem disorder characterized by
recurrent attacks of oral ulcers, genital ulcers, cutaneous lesions, and inflammatory ocular
finding. The vascular inflammatory change is known to be the main histopathology. There is no
sensitive or specific laboratory test or pathologic findings , the diagnosis relies heavily
on mucocutaneous manifestations and other clinical findings.
In the previous studies,In order to diagnose and monitor disease activity in BD, many
cytokines and biomarkers have been identified such as increased blood levels of neopterin,
a1-antitrypsin, a2- macroglobulin were correlated with disease activity. Some markers
including interleukin-6, -interleukin1b, tumor necrosis factor a (TNF-a), thrombomodulin,
E-selectin, vascular endothelial growth factor, antilysozyme(5), serum endocan, serum growth
differentiation factor (GDF-15), serum alpha 1-acid glycoprotein, and homocysteine had been
considered as inflammatory indicators in BD, However, they are not routinely used in clinical
practice as they are not simple or easily derived. Limitations of these markers also include
the reflection of short-term inflammatory activity and low discrimination ability with other
superimposed inflammatory conditions.
Currently, the platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and
similar parameters (red blood cell distribution width (RDW), mean platelet volume (MPV) and
neutrophil to lymphocyte ratio (NLR), which can be calculated from the peripheral blood
easily, have been demonstrated as a new expression of the systemic inflammatory indicators
that can aid in the diagnosis and assessment of disease severity in many diseases, such as
ankylosing spondylitis,rheumatoid arthritis,systemic lupus erythematosus,and psoriatic
Arthritis.nevertheless, only a few studies have investigated RDW, NLR, PLR, or MPV values in
patients with BD, none of which have evaluated the role of LMR in BD, not even the
relationships between LMR, PLR levels, and disease activity in patients with BD. The mean
size of the thrombocytes have been reported on the blood count as mean platelet volume (MPV).
MPV is indirectly associated with the activity of platelets. Large platelets are more active
than small ones by means of metabolic and enzymatic function. In addition, they also have a
higher potential of thrombogenicity. LMR is an easy-to-calculate indicator that can be
calculated by leukocyte subgroup of complete blood count. Also, it has been reported that LMR
ratio might have prognostic importance for some diseases. Therefore, to better understand
these serum inflammatory parameters in BD and to gain deeper insight into the roles of LMR,
MPV, NLR and PLR in BD, a prospective study to assess them all together in BD Will conducted
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03274648 -
Dietary Interventions and Butyrate Production in Behçet's Patients
|
N/A | |
Terminated |
NCT01693653 -
Tocilizumab for the Treatment of Behcet's Syndrome
|
Phase 2 | |
Completed |
NCT04961463 -
Evaluation of the Psychoeducation Program Given to Behcet's Patients in the Context of the Roy Adaptation Model
|
N/A | |
Completed |
NCT05142995 -
Sleep Related Breathing Disorders, Anxiety, Depression and Quality of Life Assessment in Behcet's Disease
|
||
Recruiting |
NCT00931957 -
Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease
|
N/A | |
Completed |
NCT03514056 -
Frequency of Fibromyalgia in Behcet Disease
|
||
Not yet recruiting |
NCT03771768 -
Diode Laser Versus Topical Corticosteroids in Management of Oral Ulcers in Behcet's Disease
|
N/A | |
Terminated |
NCT03554161 -
Tocilizumab for the Treatment of Refractory Behcet's Uveitis
|
Phase 2 | |
Recruiting |
NCT04738864 -
Neuro-ultrasound Assessment in Behcet's Disease
|
N/A | |
Completed |
NCT03264391 -
Evaluation of Macular Vascular Changes in Behcet's Disease Using Optical Coherence Tomography Angiography
|
||
Completed |
NCT04386824 -
Erectile Dysfunction in Patients With Non Ocular Behçet's Disease
|
||
Completed |
NCT03962335 -
Gut Microbiota and Behcet's Syndrome: a Dietary Intervention Trial (MAMBA Study)
|
N/A | |
Completed |
NCT01532570 -
Clinical Study of TA-650 in Patients With Behcet's Disease (BD) With Special Lesions
|
Phase 3 | |
Not yet recruiting |
NCT04186559 -
Topical Pentoxifylline Gel on Behcet's Disease Genital Ulcers
|
Phase 2 | |
Terminated |
NCT04218565 -
Golimumab for the Treatment of Refractory Behcet's Uveitis
|
Phase 2 | |
Recruiting |
NCT05200715 -
AutoInflammatory Disease Alliance Registry (AIDA)
|
||
Completed |
NCT05098678 -
Zinc Supplementation and Behçet's Syndrome
|
N/A | |
Completed |
NCT00866359 -
A Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in the Treatment of Behçet Disease
|
Phase 2 | |
Completed |
NCT00483184 -
Low Dose Interferon Alpha Treatment for Oral Ulcers of Behcet's Disease
|
Phase 2 | |
Completed |
NCT05032248 -
Uses of Tacrolimus in Behcet Disease
|
N/A |