Behavior Problem Clinical Trial
Official title:
Intranasal Dexmedetomidine Versus Oral Midazolam Premedication for Postoperative Negative Behavior Changes in Children: A Randomized Controlled Trial
The goal of this clinical trial is to learn the effect of dexmedetomidine premedication in postoperative negative behavior changes in children compared to midazolam premedication. It will also learn about the effect of dexmedetomidine and midazolam in emergence delirium. The main questions are: - Dose dexmedetomidine lower the incidence of postoperative negative behavior changes compared to midazolam? - Dose dexmedetomidine lower the incidence of emergence delirium compared to midazolam? Researchers will compare dexmedetomidine to midazolam (a common pediatric premedication) to see if dexmedetomidine works to treat postoperative negative behavior change and emergence delirium. Participants will: - Take intranasal dexmedetomidine or oral midazolam or placebo (a look-alike substance that contains no drug) premedication - Fill in the Post hospitalization behavior questionnaire for ambulatory surgery postoperative 1, 3, 7, and 30
Due to the fear of being separated from parents, fear of venipuncture, and facing unfamiliar operating room environment, children have different degrees of anxiety before surgery. Preoperative anxiety can lead to strong stress response and increase the incidence of emergence delirium. It can even cause psychological trauma and affect children's physical and mental health growth. The study showed that preoperative anxiety was positively correlated with the incidence of emergence delirium and postoperative negative behavior change, and emergence delirium was a risk factor for postoperative negative behavior in children. Currently, midazolam is the most commonly used sedative drug to relieve preoperative anxiety in children. Midazolam has anterograde amnesia effect, reducing the occurrence of intraoperative awareness, and alleviating psychological trauma and memory of malignant stimulation in children. Dexmedetomidine is a highly selective α2 adrenergic agonist with anxiolytic, sedative, and analgesic properties. Our previous study found that preoperative administration of dexmedetomidine can reduce the incidence of emergence delirium in children compared with midazolam However, no clinical studies have directly compared the effects of dexmedetomidine and midazolam premedication on postoperative negative behavior change in children. This prospective randomized controlled trial was conducted to compare the effects of dexmedetomidine and midazolam premedication on preoperative anxiety, the incidence of postoperative delirium, and postoperative negative behavior changes in children to provide a reference for optimizing clinical anesthesia medication regimens. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04725721 -
Testing FIRST in Youth Outpatient Psychotherapy
|
N/A | |
| Completed |
NCT03687879 -
Women's Evaluation of the Childbirth Experience: From Pregnancy to Postpartum
|
||
| Completed |
NCT03599648 -
The Pro-Parenting Study: Helping Parents Reduce Behavior Problems in Preschool Children With Developmental Delay
|
N/A | |
| Active, not recruiting |
NCT03641664 -
FCT Study: Reducing the Need for Out-of-Home Placements
|
N/A | |
| Recruiting |
NCT06228950 -
Mindfulness-Based Intervention for Emotional and Behavioural Problems of Students With Visual Impairment
|
N/A | |
| Recruiting |
NCT05581914 -
Effectiveness of the MY LIFE Treatment for Adolescents With Behavioral Problems
|
N/A | |
| Not yet recruiting |
NCT03260296 -
Smartphones Addiction in Assiut University Students
|
N/A | |
| Completed |
NCT02970565 -
Family Nurture Intervention, A Group Model in Connecticut
|
N/A | |
| Recruiting |
NCT05280613 -
The Family Check-Up in Autism Services
|
N/A | |
| Recruiting |
NCT05603000 -
Emotion Focused Family Therapy for Parents of Children With Mental Health Difficulties
|
N/A | |
| Completed |
NCT04547192 -
Improving Initial Management of the Injured at Ghanaian District and Regional Hospitals With a Trauma Intake Form
|
N/A | |
| Completed |
NCT05008354 -
Effect of Pyridoxine on Behavioral Adverse Events of Levetiracetam
|
Phase 4 | |
| Completed |
NCT03298724 -
Teachers and Parents as Partners During Middle School
|
N/A | |
| Completed |
NCT03709472 -
Computer Assisted Family Intervention to Treat Self-Harm Disparities in Latinas and Sexual/Gender Minority Youth
|
N/A | |
| Enrolling by invitation |
NCT04001140 -
Enhancement of Emotion Regulation Skills in Adolescents
|
N/A | |
| Active, not recruiting |
NCT05856435 -
Tailoring CPP for the Foster Care Setting
|
N/A | |
| Completed |
NCT03694314 -
Effect of Omega-3 Fatty Acids on Sleep and Behavior (Pilot Study)
|
N/A | |
| Recruiting |
NCT04298437 -
Addressing Depression and Positive Parenting Techniques (ADAPT)
|
N/A | |
| Recruiting |
NCT05667675 -
Targeting Child Mental Health and Household Poverty
|
N/A | |
| Recruiting |
NCT05273320 -
Clinical Trial of Nabilone for Aggression in Adults With Intellectual and Developmental Disabilities
|
Phase 1 |