Investigation of Mohs Surgical Margins Using Two Photon Microscopy

Status Recruiting

Clinical Trial Summary

The goal of this clinical trial is to compare the use of two photon fluorescence microscopy for detecting residual basal cell carcinoma during Mohs surgery. The main question it aims to answer is: • How similar are diagnosis of surgical margins to on two photon fluorescence microscopy compared to frozen section histology

Clinical Trial Description

This study is an study of skin cancer that will evaluate the feasibility of two photon fluorescence microscopy (TPFM) to evaluate surgical margins followed by standard of care frozen section analysis (FSA) for confirmation. To protect patients, following TPFM imaging, patients will receive standard of care evaluation using cryosectioned H&E slides, thus all patients will receive standard of care confirmation following experimental imaging. Individual excisions from consenting patients will be selected, fluorescently labeled and diagnosed using TPFM. Following imaging, specimens will be cryosectioned as per normal procedure. Following treatment, the results of the TPFM evaluation of each Mohs excisions will be compared to the results from FSA to assess the overall accuracy of TPFM and to determine if TPFM would result in changes to patient care if used without FSA confirmation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05814900
Study type	Interventional
Source	University of Rochester
Contact	Michael G Giacomelli, Ph.D
Phone	5852766260
Email	mgiacome@ur.rochester.edu
Status	Recruiting
Phase	N/A
Start date	June 20, 2023
Completion date	July 1, 2025

View Details

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