Barrett's Esophagus Clinical Trial
Official title:
The Changes of Ryodoraku and HRV After PPI Treatment in GERD Patients
Gastroesophageal reflux disease(GERD) mainly related to the reflux of stomach content induced by the dysfunction of lower esophageal sphincter. Proton pump inhibitors (PPI) can effectively block gastric acid secretion but the drug reactions and the degree of improvement in symptoms are sometimes unpredictable. The aim of this study is to investigate the association between the clinical efficacy of PPI in patients with GERD and the personal physical status by Ryodoraku and ANSWatch.
Gastroesophageal reflux disease(GERD) is a common disease, mainly related to the reflux of
stomach content induced by the dysfunction of lower esophageal sphincter. The common
symptoms of GERD are heartburn, acid regurgitation, chest pain and globus hystericus. The
methods to treat GERD are changes of lifestyle, pharmacotherapy, antireflux surgery and
endoscopy. Proton pump inhibitors (PPI) can effectively block gastric acid secretion and
promote the repair of esophagus, but the drug reactions and the degree of improvement in
symptoms are sometimes unpredictable. Recently there are many instruments used to analyze
personal physical status. Meridian energy analysis device ( Ryodoraku ) is used to assess
the energy of meridian system by analysis of resistance of the skin surface, as well as the
wrist-worn heart rate monitor (ANSWatch) used to assess the autonomic nervous system by
analysis of heart rate variability. Therefore, the aim of this study is to investigate the
association between the clinical efficacy of PPI in patients with GERD and the personal
physical status by Ryodoraku and ANSWatch.
Investigators will recruit 120 patients with GERD in clinic who have to receive PPIs for
four weeks and assess each volunteer before and after taking the medication. Assessment
methods : 1. ANSWatch to assess the autonomic nervous system, 2. Ryodoraku to assess the
energy of meridian system, 3. Upper gastrointestinal endoscopy to assess the grade of reflux
esophagitis, 4. gastroesophageal reflux disease questionnaire to assess the severity of
GERD. Investigators analysed and compared the database from the assessments between before
and after taking the medication.
Investigators anticipate to substantiate that the changes of Ryodoraku and ANSWatch are good
predictors for the clinical efficacy of PPI in patients with GERD.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening
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