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Study of Multiplexed Heptapeptides for Detection of Neoplasia in the Esophagus

Barrett Esophagus Clinical Trial

Official title:
Phase I In-vivo Study of Multiplexed Heptapeptides for Detection of Neoplasia in the Esophagus

Clinical Trial Summary

The overall aim of this feasibility study is to develop new technologies for improved detection of Barrett's neoplasia using the scanning fiber endoscope(SFE) multiplexed imaging system. This study will combine the use of fluorescent-labeled peptides that bind specifically to pre-cancerous mucosa in the esophagus for use as novel imaging agents to guide endoscopic biopsy or endoscopic mucosal resection (EMR). This Phase 1 study will be used to provide early evidence of efficacy for the topical application of a panel of two peptides that bind to molecular targets that are specific for esophageal dysplasia. A panel is needed because cancer in the esophagus is genetically heterogeneous. The study will look at peptide binding in subjects with known or suspected Barrett's esophagus.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03589443
Study type Interventional
Source University of Michigan
Contact
Status Completed
Phase Phase 1
Start date May 10, 2018
Completion date February 4, 2019
View Details
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