Comparison of Volume Controlled Ventilation and Pressure Controlled Ventilation in Laparoscopic Bariatric Surgery

Bariatric Surgery Clinical Trial

Official title:

Comparison of Volume Controlled Ventilation and Pressure Controlled Ventilation in Terms of Respiratory Mechanics in Laparoscopic Bariatric Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03758937
• Other study ID #: AntalyaTRH31
• Status: Completed
• Phase: N/A
• Start date: April 1, 2016
• Est. completion date: August 1, 2017

Study information

• Verified date: November 2018
• Source: Antalya Training and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to compare volume controlled-ventilation (VCV) and pressure-controlled ventilation (PCV) in terms of pulmonary gas exchange, respiratory mechanics and arterial blood gas values in patients undergoing laparoscopic bariatric surgery.

Description:

Today, morbid obesity has become a global problem. It is not clear which mechanical ventilation mode will be used in bariatric surgery, which is one of the treatment options of these patients. VCV is the most commonly used mode to ventilate anesthetized patients. However, especially in obese patients, high airway pressures and hypoxia may occur due to increased intrapulmonary shunts. Therefore, we aimed to investigate the potential of PCV strategy to improve pulmonary gas exchange, respiratory mechanics and arterial blood gas values according to VCV in patients undergoing bariatric surgery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 62
• Est. completion date: August 1, 2017
• Est. primary completion date: April 1, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 18 years or above,

• ASA II patients

• BMI > 40 kg / m2

• No serious comorbidity.

Exclusion Criteria:

• Unstable patients during the operation

• The requirement for mechanical ventilation in the postoperative period.

Related Conditions & MeSH terms

• Bariatric Surgery

Intervention

Procedure:
• volume-controlled ventilation

• pressure-controlled ventilation

Locations

Country	Name	City	State
Turkey	Antalya Traning and Research Hospital	Antalya

Sponsors (1)

Lead Sponsor	Collaborator
Antalya Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Partial oxygen pressure	Assessed 5 minutes after induction by using arterial blood gas analysis.	5 minutes after induction
Primary	Partial oxygen pressure	Assessed 30 minutes after pneumoperitoneum by using arterial blood gas	30 minutes after pneumoperitoneum
Primary	Partial oxygen pressure	Assessed through surgery completion, an average of 90 minutes by using arterial blood gas	through surgery completion, an average of 90 minutes
Secondary	Partial carbon dioxide pressure	Assessed 5 minutes after induction, 30 minutes after pneumoperitoneum and through surgery completion, an average of 90 minutes by using arterial blood gas analysis.	5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes
Secondary	Partial carbon dioxide pressure - end-tidal carbon dioxide pressure	Assessed 5 minutes after induction, 30 minutes after pneumoperitoneum and through surgery completion, an average of 90 minutes by using arterial blood gas analysis and end-tidal monitor.	5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes
Secondary	Peak airway pressure	Assessed 5 minutes after induction, 30 minutes after pneumoperitoneum and through surgery completion, an average of 90 minutes by using the patient monitor.	5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes
Secondary	Dynamic compliance	Assessed 5 minutes after induction, 30 minutes after pneumoperitoneum and through surgery completion, an average of 90 minutes by using formula (Tidal volume/peak airway pressure - Positive end-expiratory pressure)	5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes
Secondary	Inspired oxygen pressure / Fractional oxygen ratio	Assessed 5 minutes after induction, 30 minutes after pneumoperitoneum and through surgery completion, an average of 90 minutes	5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes
Secondary	Alveolar-arterial oxygen gradient pressure	Assessed 5 minutes after induction, 30 minutes after pneumoperitoneum and through surgery completion, an average of 90 minutes by using formula (D(A-a) O2).	5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes