Bariatric Surgery Clinical Trial
Official title:
To Define the Role of GLP-1 for Improving Glucose Homeostasis in Humans Following Gastric Bypass Surgery
There is a marked and long-lasting improvement in glucose homeostasis that follows Roux-en-y gastric bypass surgery (RYGB) in humans. This improvement has been attributed in large part to an intestinal hormone, called GLP-1, that is released into the circulation immediately after eating. The purpose of this study is to determine if GLP-1 mediates the beneficial effects of RYGB surgery on glucose homeostasis in humans.
To conduct this study, we will enroll humans who previously underwent Roux-en-Y gastric bypass surgery, who are medically and weight stable and with no signs of type 2 diabetes either before or after surgery. Potential subjects will first be screened for eligibility and also to verify that they can safely participate in the study. Each study subject will be administered a meal tolerance test (MTT) on 3 separate occasions. For the MTT, a liquid meal (Boost Plus) will be ingested following an overnight fast. A primed-continuous infusion of vehicle alone (human albumin) or xenin-25 alone (at a dose of 4 or 12 pmoles x kg-1 x min-1) will be initiated 15 minutes before the meal is ingested. Blood samples will be collected before and during the MTT for the measurement of glucose and insulin levels, as well as a host of other hormones. A comparison of the results will tell us if the effects of xenin-25 on insulin release are mediated by GLP-1 in humans. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT04517591 -
Reducing Sedentary Time in Bariatric: The Take a STAND for Health Study
|
N/A | |
| Active, not recruiting |
NCT04433338 -
The PREBA Study: Effect of Preoperative Weight Loss With a 14-day Low-calorie Diet on Surgical Procedure and Outcomes in Patients Undergoing RYGB Surgery
|
N/A | |
| Completed |
NCT05854875 -
Diabetes Remission After RYGBP and RYGBP With Fundus Resection
|
N/A | |
| Recruiting |
NCT06460233 -
Blood Pressure Changes After Bariatric Surgery
|
||
| Completed |
NCT00535600 -
Effects of Bariatric Surgery on Insulin
|
||
| Withdrawn |
NCT04771247 -
Endoscopic Cardiac Band Ligation for the Management of Refractory GERD After Laparoscopic Sleeve Gastrectomy
|
N/A | |
| Not yet recruiting |
NCT03203161 -
Registry on Obesity Surgery in Adolescents
|
||
| Enrolling by invitation |
NCT02552433 -
Complications in Body Contouring Surgery
|
||
| Completed |
NCT02525016 -
Safety Profile of IntRAvenous Lidocaine Use in Coelioscopic Bariatric Surgery
|
Phase 3 | |
| Recruiting |
NCT01984762 -
Sleeve Gastrectomy and Roux-en-Y Gastric Bypass in the Treatment of Type 2 Diabetes Mellitus.
|
N/A | |
| Not yet recruiting |
NCT01652105 -
Randomized Trial of Preoperative Diets Before Bariatric Surgery
|
N/A | |
| Completed |
NCT00989157 -
Effects of Gastric Bypass on Blood Levels of Duloxetine
|
Phase 3 | |
| Completed |
NCT03609632 -
Understanding Hypoglycaemia After Bariatric Surgery
|
N/A | |
| Completed |
NCT05454696 -
Online Clinic Pilates Exercises in Patients Undergoing Bariatric Surgery
|
N/A | |
| Completed |
NCT04040647 -
Tolerance of Early Postoperative Mobilization and Ambulation
|
||
| Recruiting |
NCT04297306 -
Virtual Reality Exercise Gaming in Patients Awaiting Bariatric Surgery
|
N/A | |
| Recruiting |
NCT05428618 -
Mobile Application for Bariatric Surgery Patients
|
N/A | |
| Not yet recruiting |
NCT03975244 -
Semi-supervised Exercise Program Before Bariatric Surgery
|
N/A | |
| Not yet recruiting |
NCT03900481 -
Use of an Endoluminal-suturing Device for Endoscopic Gastric Reduction as an Aid for Class I Obesity, or Class II Obesity Without Comorbidity
|
N/A | |
| Recruiting |
NCT06157606 -
Prediction Model for Inadequate Weight Loss After Sleeve Gastrectomy
|