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Pharmacokinetics of Paracetamol and Antiepileptic Drugs After Sleeve Gastrectomy

Bariatric Surgery Candidate Clinical Trial

Official title:
Effect of Sleeve Gastroctomy on Pharmacokinetics of Paracetamol and Antiepileptic Drugs

Clinical Trial Summary

Sleeve gastrectomy may affect drug pharmacokinetics in several potential ways. We will measure pharmakokinetics of paracetamol and antiepileptic drugs before and 6 months after sleeve gastrectomy.

Clinical Trial Description

Sleeve gastrectomy may affect drug pharmacokinetics in several potential ways. We will measure pharmakokinetics of paracetamol (in consenting subjects that are undergoing sleeve gastrectomy) and antiepileptic drugs (in consenting subjects that are chronically treated by a stable dose) before and 6 months after sleeve gastrectomy in 10 subjects. Blood tests will be taken for drug levels before and 4-8 times after the subject takes the drug. A pharmacokinetic curve will be calculated and compared for each subject between prior to surgery and after surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03161509
Study type Interventional
Source Rambam Health Care Campus
Contact
Status Terminated
Phase Phase 4
Start date July 1, 2017
Completion date January 1, 2019
View Details
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