Neuromuscular Blockade: Outcome & Recovery for Laparoscopic Bariatric

Status Completed

Clinical Trial Summary

The aim of the current observational study is to better assess the relationships between neuromuscular blockade and multiple surgical outcomes in patients undergoing elective laparoscopic bariatric surgery.

Clinical Trial Description

Performing bariatric surgery as a short-stay procedure is an ongoing trend in many centers around the world. For morbidly obese (MO) patients, the anesthetic approach is based on choosing drugs that have the least potential for accumulation. This allows a more rapid and clear-headed recovery and contributes to reduced duration of perioperative time. However, when neuromuscular blockade (NMB) is required during surgery, complete recovery is a major factor that may prevent from a rapid fast-track discharge.

In Canada, reversal of NMB is achieved by using acetylcholinesterase (AChE) inhibitors, mostly neostigmine, which must be administered after a certain level of spontaneous recovery in order to ensure a complete reversal. This elongates the time spent in the operating room (OR), and prevent therefore from a fast track surgery procedure. On the other hand, in an effort to shorten the time spent in the OR, AChE inhibitors may sometime be administered too early before spontaneous recovery, and post-operative residual curarization (PORC) may then be observed. In the post-anesthesia care unit (PACU), PORC may be particularly problematic, because of the possible occurrence of critical respiratory events (CREs). This in turn is also associated with significant delayed discharges.

Because of the aforementioned inconveniences, Canadian anesthesiologists are reluctant to induce deep NMB. Consequently, intra-abdominal pressure remain non optimal during the surgery, which do not facilitate the surgeons work, in addition to increase perioperative time. This problem is particularly frequent in cases of bariatric surgeries.

The current study will explore this question from the perspective of the surgeon satisfaction and the patient quality of recovery. ;

Study Design

Related Conditions & MeSH terms

Bariatric Surgery Candidate

Clinical Trial Details

NCT number	NCT02300168
Study type	Observational
Source	Hopital du Sacre-Coeur de Montreal
Contact
Status	Completed
Phase	N/A
Start date	September 2014
Completion date	December 2014

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05650307` - CV Imaging of Metabolic Interventions
Not yet recruiting	`NCT05536466` - The Influence of Having Bariatric Surgery on the Pharmacokinetics, Safety and Efficacy of the Novel Non-nucleoside Reverse Transcriptase Inhibitor Doravirine	N/A
Active, not recruiting	`NCT04583683` - Effects of Very Low Calorie Diet vs Metabolic Surgery on Weight Loss and Obesity Comorbidities	N/A
Completed	`NCT04099654` - The Effect of Core Stabilization Exercise Program in Obese Subjects Awaiting Bariatric Surgery	N/A
Completed	`NCT03809182` - Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels.	Phase 4
Completed	`NCT03638843` - Endoscopic Gastric Mucosal Devitalization (GMD) as a Primary Obesity Therapy - Part 2	N/A
Withdrawn	`NCT05845359` - Intraoperative Methadone for Postoperative Pain Control	Phase 4
Not yet recruiting	`NCT04343040` - Perioperative Evaluation of Glucose Profile Using Continuous Glucose Monitoring System in Glucose Intolerant Patients	N/A
Withdrawn	`NCT03095404` - Intravenous Lidocaine for Post-Operative Pain Control in Patients Undergoing Bariatric Bowel Surgery	Early Phase 1
Recruiting	`NCT03100292` - Korean OBEsity Surgical Treatment Study	N/A
Active, not recruiting	`NCT04357119` - Common Limb Length in One-anastomosis Gastric Bypass	N/A
Completed	`NCT04883268` - Focusing on Body Functionality After Bariatric Surgery	N/A
Completed	`NCT03210207` - Gastric Plication in Mexican Patients	N/A
Unknown status	`NCT01264120` - The Impact of a Bariatric Rehabilitation Service on Patient Outcomes	N/A
Recruiting	`NCT03972319` - Omega-3 Supplementation for LIver VolumE Reduction Study (OLIVER) Study	Early Phase 1
Terminated	`NCT04626232` - Comparison of the Sleeve Gastrectomy Technique With a Nissen Fundoplication Added to the Conventional Sleeve Gastrectomy Technique in Morbidly Obese Patients	N/A
Completed	`NCT03643783` - Impact of Plasma Soluble Prorenin Receptor in Obese and Type 2 Diabetic Patients
Completed	`NCT04219852` - Contraception and Bariatric Surgery: Evaluation of Contraception and Contraceptive Knowledge of Women Undergoing Bariatric Surgery at the University Hospital of Reims
Recruiting	`NCT05570474` - Effect of Protein Supplementation on Fat Free Mass Preservation After Bariatric Surgery	N/A
Recruiting	`NCT05289219` - Effects of Physical Exercise on Sarcopenia After Bariatric Surgery	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Neuromuscular Blockade: Outcome and Recovery for Laparoscopic Bariatric Surgery

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms