Hemodynamics & Vital Organ Function in Intracerebral Hemorrhage

Status Recruiting

Clinical Trial Summary

Spontaneous non-traumatic intracerebral hemorrhage (ICH) is a common symptom in clinical practice and is the most serious among all types of stroke.Recently, as a relatively mainstream and recognized INTERACT2 (five well-known international studies in the cerebrovascular field: IMS-III, MR RESCUE, SYNTHESIS EXPANSION, INTERACT2, CHANCE) studies have shown that in patients with standard systolic blood pressure Early intensive antihypertensive therapy does not increase the incidence of death or serious adverse events. The above studies confirm the safety and efficacy of early potent depression.In 2017, Anesthesiology published a META analysis of intraoperative hypotension and blood pressure versus baseline fluctuations. The final outcome showed that 20% of blood pressure in the study was similar to MAP <65 mmHg, regardless of the duration of the duration There will be postoperative myocardial and renal damage. Ischemia is a very important cause of organ damage. Myocardial injury is closely related to the level of mean arterial pressure, while ischemia and ischemic reperfusion injury are closely related to postoperative acute renal injury.There is no targeted guideline for ICH perioperative blood pressure management, especially intraoperative blood pressure management, and no previous studies have studied most of the studies involving ICH patients with conservative treatment, ICH patients with surgical treatment There are few reports on blood pressure control during surgery.

Clinical Trial Description

The general anesthesia used in craniotomy, whether intravenous anesthesia or total intravenous anesthesia, have a certain degree of blood pressure and lead to a decline in blood pressure, the study aims to spontaneous cerebral hemorrhage this special And to observe the changes of hemodynamics and the changes of heart and kidney function in ICH, and to explore the relationship between the anesthesia and the blood of ICH. The range of volatility. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03129009
Study type	Interventional
Source	Xuzhou Medical University
Contact	Jin Dong Liu, M.S
Phone	+86-13951355136
Email	liujindong1818@163.com
Status	Recruiting
Phase	N/A
Start date	April 1, 2017
Completion date	June 1, 2018

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05089331` - ROSE-Longitudinal Assessment With Neuroimaging
Recruiting	`NCT03605381` - MORbidity PRevalence Estimate In StrokE
Active, not recruiting	`NCT04522102` - Antiplatelet Secondary Prevention International Randomised Trial After INtracerebral haemorrhaGe (ASPIRING)-Pilot Phase	Phase 3
Terminated	`NCT04178746` - PRONTO: Artemis in the Removal of Intraventricular Hemorrhage in the Hyper-Acute Phase
Not yet recruiting	`NCT03956485` - Multicentre Registry of Patients With Spontaneous Acute Intracerebral Hemorrhage in Catalonia (HIC-CAT).
Enrolling by invitation	`NCT02920645` - Multicenter Validation of the AVICH Score	N/A
Recruiting	`NCT02625948` - Tranexamic Acid for Acute ICH Growth prEdicted by Spot Sign	Phase 2
Completed	`NCT02478177` - Addressing Real-world Anticoagulant Management Issues in Stroke
Completed	`NCT01971359` - Clinical Outcomes Following Parafascicular Surgical Evacuation of Intracerebral Hemorrhage: A Pilot Study	N/A
Completed	`NCT01261091` - Early Tracheostomy in Ventilated Stroke Patients	N/A
Terminated	`NCT00990509` - Albumin for Intracerebral Hemorrhage Intervention	Phase 2
Completed	`NCT00716079` - The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial	N/A
Recruiting	`NCT00222625` - rFVIIa in ICH in Patients Treated With Anticoagulants or Anti-Platelets	Phase 2
Recruiting	`NCT05095857` - The Anesthetic Ketamine as Treatment for Patients With Severe Acute Brain Injury	Phase 4
Recruiting	`NCT04548596` - NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
Not yet recruiting	`NCT06429332` - International Care Bundle Evaluation in Cerebral Hemorrhage Research	Phase 4
Recruiting	`NCT05492474` - Cranial Ultrasound for Prehospital ICH Diagnosis	N/A
Not yet recruiting	`NCT05502874` - Multicenter Registry for Assessment of Markers of Early Neurological Deterioration in Primary Intracerebral Hemorrhage
Recruiting	`NCT04604587` - MRI-visible Enlarged Perivascular Spaces and the Alteration of Lymphatic Drainage System in CAA	Phase 3
Recruiting	`NCT05504941` - Detection of an Endovascular Treatment Target in Patients With an Acute, Spontaneous Intracerebral Hemorrhage	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Hemodynamics and Vital Organ Function in Intracerebral Hemorrhage

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms