Balanced Anesthesia Clinical Trial
Official title:
Comparison of Surgical Pleth Index Guided Analgesia With Standard Clinical Practise During Balanced Anesthesia
The aim of the present study was to compare SPI guided analgesia with standard clinical practise during general anesthesia using a balanced setting of sevoflurane and sufentanil anesthesia. It was to be tested whether SPI guided analgesia leads to more cardiovascular stability, less use of analgetics and shorter recovery from anesthesia.
General anesthesia can be considered as a combination of hypnosis, antinociception, and
immobility. The monitoring of hypnosis and immobility has been established in clinical
practise, however for the evaluation of antinociception a valid monitoring is missing.
The Surgical Pleth Index (SPI; former named Surgical Stress Index-SSI) is a multivariate
index derived non invasively from finger plethysmographic signal. It has been demonstrated
to correlate with surgical stress intensity. In the setting of total intravenous anesthesia
TIVA our group could show beneficial effects of SPI guided analgesia in terms of
remifentanil consumption, hemodynamic stability and incidence of unwanted events.
Therefore, we wanted examine whether these beneficial effects of SPI guided anesthesia can
be transferred to a setting of balanced anesthesia using a volatile anesthetic sevoflurane
and the opioid sufentanil.
The following hypotheses have been made:
1. SPI guided analgesia will result in less sufentanil consumption
2. SPI guided analgesia will result in more hemodynamic stability and faster recovery of
the patient after anesthesia, and less opioid use in post operative period
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04018703 -
The Study of Different Sedative Medications in Monitored Anesthesia Care During Eye Surgery With Local Anesthesia
|
N/A | |
| Recruiting |
NCT03129009 -
Hemodynamics and Vital Organ Function in Intracerebral Hemorrhage
|
N/A |