Balance Clinical Trial - Association Between Balance & the Integrity of

Status Completed

Clinical Trial Summary

The cerebellum is involved in regulating balance and walking and plays a crucial role in the locomotor adaptation and learning processes. This study aims to investigate the association between balance and the integrity of the cerebellar white matter tracts in a healthy population. Healthy participants will undergo four weeks of balance training. The investigators will analyze changes in the microstructural integrity of the cerebellar white matter tract before and after four weeks of balance training.

Clinical Trial Description

The cerebellum is involved in regulating balance and walking and plays a crucial role in the locomotor adaptation and learning processes. The cerebellum's intermediate zone, which receives afferent stimuli from the sensorimotor cortex (via the cortico-ponto-cerebellar tract) and peripheral muscles (via the dorsal spinocerebellar tract), contributes to maintaining body posture and regulating walking. Proprioceptive information from the peripheral muscles passes through the dorsal spinocerebellar tract, enters the ipsilateral cerebellar hemisphere via the inferior cerebellar peduncle, and finally projects to the contralateral motor cortex through the cerebello-thalamo-cortical pathways. Diffusion tensor imaging (DTI) enables microstructural evaluation of the white matter tracts. Both diffusion tensor tractography, to determine the structural connectivity of the whole tract, and DTI-derived parameters, to determine the microstructural organization, can represent the integrity of the cerebellar white matter tracts. The investigators will evaluate the motor-related white matter tracts, including the corticospinal tract, the cortico-ponto-cerebellar tract, the dorsal spinocerebellar tract, and the dentato-rubro-thalamo-cortical tract. Healthy participants will perform the four weeks of balance training, and DTI will be acquired before and after exercise. The investigators will analyze the DTI-derived parameters of the relevant white matter tracts and analyze the longitudinal changes. The investigators hypothesized that the four weeks of balance training would enhance the integrity of the cerebellar white matter tracts. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04934319
Study type	Interventional
Source	The Catholic University of Korea
Contact
Status	Completed
Phase	N/A
Start date	May 24, 2021
Completion date	December 31, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04039048` - Effect of ctDCS During Balance Training on Cerebellar Ataxia	N/A
Not yet recruiting	`NCT04105322` - Effects of Kinesio Taping on Balance and Functional Performance in Stroke Patients	N/A
Completed	`NCT00934531` - Donepezil and the Risk of Falls in Seniors With Cognitive Impairment	N/A
Completed	`NCT05563311` - Functional Assessment and Sleep Apnea in Obese Children and Adolescents	N/A
Completed	`NCT03674268` - Psycometric Properties of Pushing Scale
Completed	`NCT03403218` - Spanish Version of the Balance Evaluation Systems Test and Mini Balance Evaluation Systems Test	N/A
Completed	`NCT04563182` - Relationship Between Gluteus Medius Muscle Strength, Balance and Jumping Performance in Professional Female Handball Players
Recruiting	`NCT05983809` - Technological Balance and Gait Rehabilitation in Patients With Multiple Sclerosis.	N/A
Completed	`NCT05779189` - Effects of Game-based Virtual Reality Intervention on Senior Fitness, Fall Prevention and Balance Function Among Older Adults	N/A
Completed	`NCT04671524` - The Effect of Improvement in Function on Foot Pressure, Balance and Gait in Children With Upper Extremity Affected	N/A
Completed	`NCT06405854` - Coordination-based Exercise Intervention in Preschool Children	N/A
Not yet recruiting	`NCT06267833` - The Effect of Trunk and Upper Extremity Exercises Added to the Otago Exercise Program	N/A
Active, not recruiting	`NCT05910606` - Strong Foundations 2.0: A Digitally Delivered Fall Prevention Program.	N/A
Not yet recruiting	`NCT05973279` - The Relationship Between Lower Limb Functionality, Knee Joint Position Sense, Balance and Falls in Haemiplegic Patients
Active, not recruiting	`NCT03892291` - Objective Dual-task Turning Measures for Return-to-duty Assessments
Completed	`NCT05043727` - Effects of Exer Gaming on Balance and Gait in Parkinson's Patients	N/A
Completed	`NCT04014998` - Effectiveness of Virtual Reality in Patients With Chronic Neck Pain	N/A
Completed	`NCT01698086` - Vestibular Rehabilitation for Persons With Multiple Sclerosis: Who Benefits the Most? (MSVR3trial)	N/A
Completed	`NCT03376334` - A Pilot Study to Investigate the Effect of Motor Imagery on Dynamic Balance of Asymptomatic Students	N/A
Completed	`NCT05319626` - Immediate Effects of Two Different Lower Limb Sensory Stimulation Strategies on Balance and Mobility in Older Adults	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Association Between Balance and the Integrity of Cerebellar White Matter Tracts in a Healthy Population

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms