Bacterial Vaginosis Clinical Trial
The primary aim of the present study is to investigate the vaginal microbiota of infertile
women with two novel molecular based diagnostic tests for Bacterial Vaginosis, a PNA FISH
and a PCR method supported with conventional Gram staining.
We hypothesize that the molecular based tests will prove more efficient than conventional
Gram staining and that they have a place in future IVF diagnostics.
Our first aim is to investigate the prevalence of altered vaginal microbiotas among women
seeking fertility treatment in Denmark. Secondly we want to establish whether there are
correlations between altered vaginal microbiotas and self-measurements of both the vaginal
pH performed with the Saling pH glove™ and a self-collected swab with Copan Eswab™ because
these would be useful for an easy-access longitudinal screening option. Finally, the third
aim was to explore how the species composition of vaginal microbiotas measured by a
multiplex qPCR assay was reflected in Nugent scores.
A possible 4th aim is to identify patterns in the relative abundances of different species
with 16sRNA primers among fertile women compared with infertile women because these
differences could be indicative of a vaginal microbiota associated with bad fertility
outcome.
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Observational Model: Cohort, Time Perspective: Prospective
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