Bacteremia Clinical Trial
Official title:
Diagnostic Performance of Plasma Procalcitonin in Screening for Contamination When Detecting Potential Contaminants in Blood Cultures
In blood cultures, species considered as potentially contaminating (coagulase negative
staphylococci (CNS), Bacillus spp., Corynebacterium spp., Cutibacterium acnes, Micrococcus
spp., viridans group streptococci, and Clostridium perfringens) can, however, be responsable
for true bacteremia.
Blood levels of the prohormone procalcitonin (PCT) markedly increase in the early stages of
bacterial infections. The aim of our study is to determine the role of plasma PCT as a
biomarker differentiating blood culture contaminations from true bacteremia.
Blood culture contamination is defined by the introduction into of a microorganism into blood
culture bottles from either the patient's or healthcare worker's flora, or the immediate
environment during specimen collection. Species considered as potentially contaminating
(coagulase negative staphylococci (CNS), Bacillus spp., Corynebacterium spp., Cutibacterium
acnes, Micrococcus spp., viridans group streptococci, and Clostridium perfringens) can,
however, be responsible for true bacteremia. If an organism belonging to one of those species
is detected in isolates, rapidly and accurately assessing its contaminant or infectious
potential is hence important to ensure effective antibiotic therapy as well as to reduce
financial burden caused by unnecessary treatments, and additional clinical and laboratory
costs.
Blood levels of the prohormone procalcitonin (PCT) markedly increase in the early stages of
bacterial infections. The aim of our study is to determine the role of plasma PCT as a
biomarker differentiating blood culture contaminations from true bacteremia.
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