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Bacillary Dysentery clinical trials

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NCT ID: NCT05961059 Not yet recruiting - Shigellosis Clinical Trials

InvaplexAR-Detox and dmLT Adjuvant in the Netherlands and Zambia

SUNSHINE
Start date: November 2023
Phase: Phase 1
Study type: Interventional

The goal of this clinical trial is to test a new Shigella vaccine (InvaplexAR-DETOX) in combination with a new adjuvant (dmLT) in healthy participants. The main questions it aims to answer are: - Is the new Shigella vaccine (with and without the new adjuvant) safe and well tolerated? - How wel does the new Shigella vaccine stimulate the immune system in combination with the new adjuvant, and without the new adjuvant? Participants will receive three vaccinations at 28-day intervals. Researchers will compare the results of participants vaccinated with the vaccine in combination with the adjuvant to the results of participants vaccinated with the vaccine only and to the results of participants vaccinated with a placebo (fake vaccine).

NCT ID: NCT02797236 Completed - Shigellosis Clinical Trials

SF2a-TT15 Conjugate Vaccine in Healthy Adult Volunteers

Start date: September 2016
Phase: Phase 1
Study type: Interventional

This is a first-in-human, single-center, single-blinded, observer-masked randomized, dose escalation (two doses), placebo-controlled study in healthy volunteers.

NCT ID: NCT02445963 Completed - Shigellosis Clinical Trials

Safety and Immunogenicity of Artificial Invaplex (Shigella Flexneri 2a InvaplexAR)

Start date: October 1, 2015
Phase: Phase 1
Study type: Interventional

This study is an open-label, dose-escalating Phase 1 investigation of S. flexneri 2a InvaplexAR vaccine. A total of up to 40 subjects will receive one of four S. flexneri 2a InvaplexAR vaccine doses. The vaccine will be administered intranasally (without adjuvant).

NCT ID: NCT01612572 Unknown status - Bronchitis Clinical Trials

A Registry Study on Xiyanping(a Chinese Medicine Injection) Used in Fifty Hospitals

Start date: January 2012
Phase: N/A
Study type: Observational

This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in October 2011. It was funded by China major scientific and technological specialized project for 'significant new formulation of new drugs'. Xiyanping is kind of Chinese Medicine injection used for treating viral pneumonia 、bronchitis、amygdalitis、infantile diarrhea、bacillary dysentery 、virus hepatitis、and Children acute hot diseases in many Chinese hospitals. The purpose of this study is to determine adverse drug events or adverse drug reaction in large sample size 20,000 patients.