Does CMV Induced Changes in NK Lymphocyte Biology Influence the Effectiveness of Antibody Therapy Used to Treat B Cell Lymphoproliferative Diseases?

B Cell Non-Hodgkin's Lymphoma Clinical Trial

Official title:

Does CMV Induced Changes in NK Lymphocyte Biology Influence the Effectiveness of Antibody Therapy Used to Treat B Cell Lymphoproliferative Diseases?

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03417414
• Other study ID #: GNK Cells in CLL and NHL
• Status: Not yet recruiting
• Phase: N/A
• First received: December 15, 2017
• Last updated: February 5, 2018
• Start date: March 1, 2018
• Est. completion date: March 1, 2021

Study information

• Verified date: February 2018
• Source: Ottawa Hospital Research Institute
• Contact: Harold Atkins, MD FRCPC
• Phone: 613-737-7700
• Email: hatkins[@]toh.ca
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This is an observational cohort study of patients with a new diagnosis of B cell Chronic Lymphocytic Leukemia or B cell Non-Hodgkin's Lymphoma who will receive an anti-CD20 monoclonal antibody treatment during the induction phase of their treatment. Throughout the study, patients will have four blood draws at specified time points throughout the study. The initial blood draw will be analysed test patients for Cytomegalovirus and conduct a g-NK cell analysis. The final three blood draws will be conducted to analyse the g-NK cells at specified time points. The objectives of this study are to: 1) characterize the frequency of CMV (+) and g-NK (+) individuals in the B-NHL and B-CLL populations, 2) Determine changes in circulating g-NK cells during and after anti-CD20 monoclonal antibody containing remission induction chemotherapy and 3) Evaluate whether the presence of g-NK cells improve the outcome of anti-CD20 monoclonal antibody containing remission induction treatment of patients with B-NHL or B-CLL.

Description:

CMV infection results in a unique population of highly effective ADCC effector cells (g-NK) in more than 50% of individuals. Unlike most NK cells, g-NK cells are long-lived and persist for years following primary infection. The g-NK population enlarges following antibody binding through their Fc receptors (FcR) and target engagement by the antibody. The addition of rituximab and other monoclonal antibodies directed against B lymphocyte targets to remission-induction therapy has improved the depth and durability of response for patients with B cell lymphoproliferative diseases, such as Non-hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL). The effects of rituximab and other monoclonal anti-cancer antibodies are at least partially mediated through ADCC mechanisms.

The purpose of this study is to examine the clinically relevant aspects of g-NK biology during antibody-containing therapy of lymphoproliferative diseases including whether the presence of g-NK might correlate with improved treatment responses.

Up to 160 patients with either B cell NHL or CLL will be enrolled in this study.

The study enrollment will occur over approximately 2 years. Patients will only be involved in this study until their blood samples are collected at the time point described below.

The following data will be abstracted from the clinical record over the course of the study:

• Age (at beginning of remission-induction therapy)

• Gender

• Weight and height

• Pathological diagnosis including subtype and genetic testing when available.

• Stage at diagnosis

• Prognostic index score (IPI or FLIPI as appropriate)

• Date that remission-induction therapy begins

• Chemotherapy used for remission-induction.

• Dose of anti-CD20 antibody administered during remission-induction

• Remission status after 3 cycles of remission-induction therapy (if available)

• Details of maintenance therapy (drug, dose, schedule)

• Date of progression or relapse.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 160
• Est. completion date: March 1, 2021
• Est. primary completion date: March 1, 2021
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• New diagnosis of CD20 expressing B-NHL or CLL

o Up to 1/3rd of enrolled patients may have CLL. Enrollment of patients with CLL will be halted if this criterion is reached.

• Will receive an anti-CD20 monoclonal antibody treatment (including rituximab, obinatuzumab) during the induction phase of treatment

• Has not previously received cytotoxic chemotherapy medications

• Able to provide informed consent

Exclusion Criteria:

• Comorbidities or frailty that would limit estimated survival to <1 year.

• Will not receive active anti-CD20 containing remission induction therapy.

Related Conditions & MeSH terms

• B Cell Lymphocytic Leukemia
• B Cell Non-Hodgkin's Lymphoma
• Leukemia, B-Cell
• Leukemia, Lymphocytic, Chronic, B-Cell
• Leukemia, Lymphoid
• Lymphoma, B-Cell
• Lymphoma, Non-Hodgkin
• Lymphoproliferative Disorders

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Ottawa Hospital Research Institute

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Is the presence of gNK cells associated with better clinical responses in rituxan treated lymphoma patients?	Blood samples will be collected at 4 specified time points from each participant.	2 years
Secondary	Are circulating gNK cells capable of killing CD20+ lymphoma cells through rituximab mediated ADCC mechanisms.	Blood samples will be collected at 4 specified time points from each participant.	2 years