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Clinical Trial Summary

Chimeric antigen receptor (CAR) T cells targeting CD19 will be evaluated for safety and efficacy in patients with B cell malignancy including lymphoma or leukemia.


Clinical Trial Description

The CAR consists of a CD19 targeting antibody scFv with three intracellular signaling domains derived from CD3 zeta, CD28 and 4-1BB. Autologous T cells will be gene engineered with the CAR gene using a lentivirus vector. Prior to T cell infusion, the patients will be subjected to preconditioning treatment. After T cell infusion, the patients will be evaluated for 24 months for adverse reactions, persistence of CAR T cells and efficacy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02963038
Study type Interventional
Source Hebei Senlang Biotechnology Inc., Ltd.
Contact jianqiang li, PhD & MD
Phone +8631189928689
Email limmune@gmail.com
Status Recruiting
Phase Phase 1/Phase 2
Start date June 2016
Completion date June 2021

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