Clinical Trials Logo
  1. Home
  2. B-cell Lymphoma Refractory
  3. NCT01535989

Study of Inotuzumab Ozogamicin + Temsirolimus in Patients With Relapsed or Refractory CD22+ B-cell NHLymphoma — IOSI-LND-001  

B-cell Lymphoma Refractory Clinical Trial

Official title:
A Phase I Study of Inotuzumab Ozogamicin (CMC-544) in Combination With Temsirolimus (CCI-779) in Patients With Relapsed or Refractory CD22-positive B-cell Non Hodgkin's Lymphomas

Clinical Trial Summary

This is an open label phase I study of Inotuzumab Ozogamicin, an antibody-targeted intravenous chemotherapy agent composed of a CD22-targeted antibody linked to calicheamicin, in combination with the mammalian target of rapamycin (mTOR) inhibitor Temsirolimus, in patients with relapsed/refractory CD22+ B-cell non Hodgkin's lymphomas (NHLs). Both Inotuzumab Ozogamicin and Temsirolimus have been evaluated as single agents as well as in combination with rituximab in patients with NHLs. This is the first study combining the two agents together. In the present study Inotuzumab Ozogamicin will be administered intravenously on d1 at the starting dose of 0.8 /m2. Temsirolimus will be administered intravenously on days 1,8,15 and 22 at the starting dose of 15mg. Cycles will be repeated every 28 days.

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01535989
Study type Interventional
Source Oncology Institute of Southern Switzerland
Contact
Status Completed
Phase Phase 1
Start date December 2011
Completion date June 2016
View Details
See also
  Status Clinical Trial Phase
Enrolling by invitation NCT05645744 - Long-term Follow-up Study in Patients Previously Treated With a Mustang Bio CAR-T Cell Investigational Product.
Active, not recruiting NCT03664635 - MB-CART20.1 Lymphoma Phase 1/Phase 2
Recruiting NCT03853616 - MB-CART19.1 r/r CD19+ B-cell Malignancies (BCM) Phase 1/Phase 2
Recruiting NCT06445803 - CD19/CD22 CAR-T Cells in Adults With R/R ALL or NHL Phase 1
Recruiting NCT05360238 - Study to Assess Safety, Tolerability and Efficacy of MB-106 in Patients With Relapsed or Refractory B-Cell NHL or CLL Phase 1/Phase 2
Not yet recruiting NCT04303247 - CD19 and CD22 Dual-targeted CAR-T Cells for Relapsed or Refractory B-NHL Early Phase 1
Recruiting NCT05318963 - Targeting CD19/CD20/CD22 Triple-targeted Cell in Patients With Relapsed/Refractory B-cell Lymphoma Phase 1
Active, not recruiting NCT04531046 - Axi-Cel as a 2nd Line Therapy in Patients With Relapsed/Refractory Aggressive B Lymphoma Ineligible to Autologous Stem Cell Transplantation Phase 2
Not yet recruiting NCT05705570 - A Phase I Clinical Trial Using Genetically Engineered Autologous T Cells to Express Chimeric Antigen Receptor (CAR) for Treatment of Patients With Refractory or Relapsed CD19-positive B Lymphoid Malignancies Phase 1
Active, not recruiting NCT04304040 - A Study of MIL62 Combined With Orelabrutinib for the Treatment of R/R CD20+B Cell Lymphoma Phase 1/Phase 2
Not yet recruiting NCT05909098 - Safety and Efficacy of Autologous NK Cell Adjuvant Therapy for Relapsed/Refractory Non-Hodgkin's B-cell Lymphoma Phase 1/Phase 2
Recruiting NCT04747093 - Induced-T Cell Like NK Cells for B Cell Malignancies Phase 1/Phase 2
Completed NCT05130489 - CAR T Cell Therapy Related Cardiovascular Outcomes
Recruiting NCT01786018 - Thiotepa, Busulfan and Fludarabin for pt With Refractory/Early Relapsed Aggressive B-cell Non Hodgkin Lymphomas Phase 2
Recruiting NCT06220097 - Mitoxantrone Hydrochloride Liposome Injection-containing Bridging Regimen and CD19-targeting CAR-T Therapies Phase 2
Active, not recruiting NCT04214886 - CD19 Chimeric Antigen Receptor (CAR) T Cells for Adults With Recurrent or Refractory B Cell Malignancies Phase 1