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Clinical Trial Summary

This is an open, single-arm, clinical study to evaluate efficacy and safety of anti CD19 CAR-T cell in the treatment of recurrent or refractory B-ALL


Clinical Trial Description

The CARs consist of an anti-CD19 single-chain variable fragment(scFv) that was derived from the FMC63 mouse hybridoma, a portion of the human CD137(4-1BB) molecule, and the intracellular component of the human CD3ζ molecule. Prior to CAR-T cell infusion, the patients will be subjected to preconditioning treatment. After CAR-T cell infusion, the patients will be evaluated for adverse reactions and efficacy.

The Main research objectives:

To evaluate the safety and efficacy of 1904B in patients with recurrent or refractory B-ALL

The Secondary research objectives:

To investigate the cytokinetic characteristics of 1904B in patients with recurrent or refractory B-ALL ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04546893
Study type Interventional
Source Hebei Senlang Biotechnology Inc., Ltd.
Contact Peihua Lu, PhD&MD
Phone 008618611636172
Email peihua_lu@126.com
Status Recruiting
Phase N/A
Start date September 1, 2020
Completion date December 1, 2022

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