B-ALL Clinical Trial
Official title:
Safety and Efficacy Study of SL1904B CAR-T Cells for Relapsed or Refractory B-Cell Acute Lymphocyte Leukemia
This is an open, single-arm, clinical study to evaluate efficacy and safety of anti CD19 CAR-T cell in the treatment of recurrent or refractory B-ALL
The CARs consist of an anti-CD19 single-chain variable fragment（scFv） that was derived from
the FMC63 mouse hybridoma, a portion of the human CD137（4-1BB） molecule, and the
intracellular component of the human CD3ζ molecule. Prior to CAR-T cell infusion, the
patients will be subjected to preconditioning treatment. After CAR-T cell infusion, the
patients will be evaluated for adverse reactions and efficacy.
The Main research objectives:
To evaluate the safety and efficacy of 1904B in patients with recurrent or refractory B-ALL
The Secondary research objectives:
To investigate the cytokinetic characteristics of 1904B in patients with recurrent or
refractory B-ALL
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