Hormonal Stimulation of Spermatogenesis

Azoospermia, Nonobstructive Clinical Trial

Official title: Hormonal Stimulation of Spermatogenesis in Non-obstructive Azoospermia

Status Completed

Clinical Trial Summary

Urologists and reproductive specialists are often challenged when facing patients with severe male infertility scenarios. In particular, the treatment of men with NOA demands a deeper insight. In such cases, .

Clinical Trial Description

The hormonal stimulation of spermatogenesis is still being explored. Thus, there is still little knowledge regarding the type of patient who might benefit from medical treatment, the optimal medication, the regimen, and the duration of treatment. In male infertility, the induction for treatment with follicle stimulating hormone (FSH) in the induction and maintenance of spermatogenesis in patient with hypogonadotopic hypogonaism. As these patients are normally azoospermic without gonadotropin stimulation and during testosterone therapy The presence of high numbers of progressively motile and normally formed sperms in the ejaculate during exogenous gonadotropin therapy might result in the desired clinical pregnancy for many infertile couples on an experimental basis and in some places already in clinical routine. FSH preparation are also used for treatment of normogonadotopic infertile men with idiopathic impairment of spermatogemesis. Pulstile GnRH or exogenous gonadotropins are usually used to induce spermatogenesis and promote testicular enlargement .The regimen for gonadotropin replacement includes an initial use of human chorionic gonadotropin (HCG) for 6 to 12 months and then addition of FSH or human menopausal gonadotropins (HMG) until pregnancy ;

Related Conditions & MeSH terms

• Azoospermia
• Azoospermia, Nonobstructive

• NCT number: NCT05483621
• Study type: Interventional
• Source: Egymedicalpedia
• Status: Completed
• Phase: Phase 1
• Start date: March 1, 2021
• Completion date: March 1, 2022